Pain After Buffered Vs Non Buffered Articaine

A Comparison of Pain Response During Administration of Buffered Articaine Versus Non-buffered Articaine Local Anesthetics for Dental Treatment in Adult

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06538233

Enrollment

108

Registered

2024-08-05

Start date

2024-01-01

Completion date

2025-01-31

Last updated

2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Brief summary

Pain after buffered versus non buffered articaine.

Interventions

DRUGBuffered articaine

Injecting buffered articaine in maxillary anterior region and evaluate pain response.

DRUGNon buffered articaine

Injecting non buffered articaine in maxillary anterior region and evaluate pain response.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Males and females, age- 18 to 60 yrs. * Medically free. * Need a dental treatment in the upper anterior region.

Exclusion criteria

* Periodontally affected teeth. * Radiographic bone loss. * Upnormal length of the teeth.

Design outcomes

Primary

Measure	Time frame	Description
Numerical Rate Scale (NRS)	Immediate	Pain during injection of buffered versus non-buffered articaine local anesthetic will be measured using NRS from 0 to 10, where 0 is no pain and 10 is the most unbearable pain .

Countries

United States

Contacts

Primary ContactPavanpreet Kaur, Resident

p.kaur@cdiohio.org2163551155

Backup ContactJana Aboul-Hassan, Resident

j.aboulhassan@cdiohio.org7262054266

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026