Moderate Traumatic Brain Injury, Testican-1, Ubiquitin
Conditions
Brief summary
We aimed to determine if testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course (presence of intraparenchymal pathology) and mortality in patients with moderate traumatic brain injury.
Detailed description
The study specifically included patients over 18 years of age with moderate TBI (GCS: 9-13) who provided informed consent. The control group consisted of healthy individuals without any disease who voluntarily participated in the study. Patients with moderate TBI were divided into two groups: those with intracranial pathology (Subdural hemorrhage, epidural hemorrhage, subarachnoid hemorrhage, intraparenchymal hemorrhage, and contusion) and those without. Treatment was initiated according to ATLS in patients with moderate TBI, and blood samples taken at the time of admission to the emergency department were placed in Ethylenediaminetetraacetic acid (EDTA) tubes. The relationship between the patient's clinical scoring (GCS, ISS and AIS), brain CT results, and mortality status with testican-1 and ubiquitin levels was compared.
Interventions
DIAGNOSTIC_TESTTestican-1
Testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course and mortality in patients with moderate traumatic brain injury.
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* being over 18 years old * having a GCS score between 9 and 13
Exclusion criteria
* under 18 years of age * had missing data * were pregnant * had neurodegenerative disease * had Central Nervous System (CNS) infection * had cerebral palsy * had penetrating head injury (by a cutting or piercing tool such as a firearm, knife, axe) * patients with severe (GCS: 3-8) or mild (GCS: 14-15) TBI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of testican-1 and ubiquitin levels in patients with moderate traumatic brain injuries and a control group | The study was conducted with blood samples taken at the time of admission. | We compared the plasma blood levels of biomarkers in both groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ROC curve analysis for the prediction of intraparenchymal pathology (+) | The study was conducted with blood samples taken at the time of admission. | We investigated the diagnostic value of biomarkers in detecting pathology on brain CT in patients with moderate traumatic brain injury. |
Countries
Turkey (Türkiye)
Outcome results
None listed