Heat Stroke
Conditions
Brief summary
Heat stroke is a life-threatening clinical syndrome characterized by an imbalance between heat production and heat dissipation in the body, resulting from exposure to hot and humid environments and/or strenuous exercise. It is defined by an elevated core temperature exceeding 40°C and central nervous system abnormalities, accompanied by multi-organ dysfunction. The severity of cellular and tissue damage in heat stroke patients depends on the peak temperature reached and the duration of hyperthermia. Rapid reduction of core temperature can halt cellular damage, quickly reverse organ dysfunction, and improve patient outcomes. Therefore, early identification and rapid cooling are crucial to prevent irreversible damage and death in heat stroke patients. However, there is a lack of systematic and specific protocols to guide emergency medical staff in the standardized and effective management of body temperature in heat stroke patients. To address this, our research team previously developed an early in-hospital temperature management protocol for heat stroke patients based on the best available evidence, expert consultations, and expert panel meetings. This study aims to validate the feasibility and effectiveness of the protocol through clinical research, providing a basis for clinical practice.
Interventions
OTHERthe early in-hospital temperature management protocol for heat stroke patients
The early in-hospital temperature management protocol for heat stroke includes early identification, selection of cooling methods for rapid cooling, precise target temperature management, and dynamic monitoring. Effective temperature management will be implemented for heat stroke patients to improve their outcomes.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Jinhua Municipal Central Hospital
Yiwu Central Hospital
Dongyang People's Hospital
Jinhua People's Hospital
Lanxi People's Hospital
Yongkang No.1 People' s Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the emergency department and diagnosed with heat stroke according to the China expert consensus on Heat Stroke
Exclusion criteria
* transferred from another hospital and body temperature \< 39.5℃; discharged within 4 hours, and subsequent body temperature or outcomes were unavailable; required immediate cardiopulmonary resuscitation; had other serious diseases, such as massive cerebral haemorrhage or severe trauma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cooling rate at 0.5 hours | 0.5 hours | The cooling rate at 0.5 hours was calculated in reference to initial body temperature and body temperature at 0.5 hours |
| Body temperature at 0.5 hours | 0.5 hours | Body temperature at 0.5 hour refers to a reading obtained 25 to 35 minutes after admission. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body temperature at 2 hours | 2 hours | Body temperature at 2 hours refers to a reading taken 100 to 140 minutes after admission |
| in-hospital mortality | 30 days | Mortality from any cause during hospitalization |
| 3-month mortality rate | 3 months | death within 3 months after emergency visit |
| Number of participants with other complications | 3 months | including heart failure, renal failure, coagulation disorders, respiratory failure, neurological sequelae, etc. |
Countries
China
Contacts
CONTACTXiuqin Feng
CONTACTlan chen
STUDY_CHAIRlan chen
Second Affiliated Hospital, School of Medicine, Zhejiang University
Outcome results
None listed