High Frequency Jet Ventilation Versus Conventional Positive Pressure Ventilation for EBUS

Comparison of High Frequency Jet Ventilation and Conventional Positive Pressure Ventilation for Endobronchial Ultrasound Examinations

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06537388

Enrollment

428

Registered

2024-08-05

Start date

2024-08-15

Completion date

2025-05-01

Last updated

2025-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High-Frequency Jet Ventilation, Intermittent Positive-Pressure Ventilation, Ultrasonography, Interventional

Brief summary

Endobronchial ultrasound (EBUS) is frequently used in pneumology for diagnostic procedures like mediastinal biopsies. This procedure is usually done under general anesthesia. Different methods of ventilation are used according to center and physician preferences. In this retrospective study, complications of 2 types of ventilation will be analyzed: * High frequency jet ventilation (HFJV) * Conventional intermittent positive pressure ventilation (IPPV) Descriptive statistics will be used to present the data. Both ventilation techniques will be compared after propensity score matching. For HFJV patients from 2019 will be analyzed and for IPPV patients from 2023, as the team changed its practice over time.

Interventions

PROCEDUREVentilation type

Type of ventilation used during the EBUS procedure, either HFJV or IPPV

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All patients who underwent EBUS at Erasme University Hospital using either HFJV or IPPV between january 1st 2019 and december 31st 2019 or january 1st 2023 and december 31st 2023.

Exclusion criteria

* Incomplete medical chart * Patients who expressed an opposition to the use of their medical data * Age \< 18 years

Design outcomes

Primary

Measure	Time frame	Description
Hypoxia	24 hours	defined as an SpO2 \< 90% for more than 1 min
Severe hypoxia	24 hours	defined as an SpO2 (oxygen saturation by pulse oximetry) \< 85% for more than 1 min
Hemodynamic instability	24 hours	defined as a systolic arterial blood pressure \< 90/60 mm Hg
Cardiac arrythmia	24 hours	Any cardiac rhythm other than sinus rhythm
Laryngospasm	24 hours	Any occurence of laryngospasm
ICU admission	24 hours	Necessity for admission to the intensive care unit (ICU)

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026