Chronic Lymphocytic Leukemia, Monoclonal B-Cell Lymphocytosis
Conditions
Brief summary
This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.
Detailed description
PRIMARY OBJECTIVES: I. Determine the cellular and mechanistic basis of bone marrow (BM) hematopoietic dysfunction in untreated MBL and CLL patients. II. Determine if MBL and CLL B cell derived cellular products directly alter the differentiation and functional capacities of Hematopoietic Stem and Progenitor Cells (HSPCs). III. Utilize the Emu-Tcl1 transgenic mouse model to determine how MBL and CLL patient-derived cellular products alter BM hematopoiesis. OUTLINE: This is an observational study. Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study.
Interventions
OTHERNon-Interventional Study
Non-interventional study
Sponsors
Mayo Clinic
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who * Remain untreated * Are currently being treated * Who have already been treated * Subjects in the MBL cohort will have a clinically established diagnosis of MBL * Healthy age-matched control subjects * Healthy younger control subjects aged \> 40 years
Exclusion criteria
* Anyone under 40 * Healthy control subjects must not have a diagnosis of CLL or MBL
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of MBL on bone marrow function | Baseline | Samples collected from healthy participants and participants with MBL will be compared for differences in bone marrow function (i.e., ability to fight off infection). Results will be descriptive. With participant permission, samples will be stored for future research use. |
| Effects of CLL on bone marrow function | Baseline | Samples collected from healthy participants and participants with CLL will be compared for differences in bone marrow function (i.e., ability to fight off infection). Results will be descriptive. With participant permission, samples will be stored for future research use. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORNeil E. Kay, M.D.
Mayo Clinic in Rochester
Outcome results
None listed