Postoperative Pain
Conditions
Brief summary
Comparison of intraperitoneal instillation of bupivacaine with dexmedetomidine versus bupivacaine with dexamethasone on postoperative pain after laparoscopic cholecystectomy
Detailed description
Laparoscopy has become the preferred mode for many diagnostic and operative procedures. It has the advantage better cosmetic results, faster recovery, short post-operative hospital stays, and early resumption of normal activities. Post-laparoscopic pain results from stretching of the intra-abdominal cavity, peritoneal inflammation, and diaphragmatic irritation caused by residual carbon-dioxide in the peritoneal cavity is very annoying to the patients. Although the severity of pain after a laparoscopic procedure is less compared to laparotomy, but it is acute and can lead to increased analgesic requirements and prolonged hospital stays. Several studies have evaluated post-laparoscopic pain relief methods such as intravenous analgesics analgesic patches, steroids, and intra-peritoneal instillation of local anaesthetics alone or with additives.
Interventions
COMBINATION_PRODUCTbupivacaine with dexamethasone
intra-peritoneal instillation of bupivacaine with dexamethasone (received 40 mL of 0.25% bupivacaine + 16 mg dexamethasone with 5 ml normal saline).
COMBINATION_PRODUCTbupivacaine with dexmedetomidine
intra-peritoneal instillation of bupivacaine with dexmedetomidine (received 40 mL of 0.25% bupivacaine + dexmedetomidine 1 μg/kg with normal saline 5 ml).
Sponsors
Aswan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients scheduled for laparoscopic cholecystectomy * Age 18-60 years * American Society of Anesthesiologists (ASA) physical status I-II
Exclusion criteria
* Patients with diabetes mellitus * Allergy to the study drugs * Patients on steroids * Pregnant females * Patients with cardiac, pulmonary, hepatic or renal disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence and severity of postoperative pain for 24 hours | severity of postoperative pain measured at 1, 2, 4, 8, 16, and 24 hours. postoperatively, using Visual Analogue Scale | using VAS pain score |
Countries
Egypt
Outcome results
None listed