Acute Postoperative Pain, Oxycodone, Thoracoscopic Lobectomy
Conditions
Brief summary
The goal of this clinical trial is to measure the median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy. This clinical trial was divided into two groups based on age, Group I (Age \< 65 years old) and Group II (Age ≥65 years old). We used the sequential allocation designed by Dixon. The initial oxycodone dose was set to 0.1 mg/kg.A satisfactory or an unsatisfactory analgesic response of the previous patient determined, respectively, the relative 10% decrease or increase in the dose of oxycodone the next patient received in the same group. The patient before the first crossover point was included as the first case for ED50 estimation in each group.The study was conducted until 7 crossover points were collected
Interventions
DRUGOxycodone will be administered intravenously in the group 1
Oxycodone will be administered intravenously 30min before the end of surgery, and Dixon sequential method will be used for the study
Sponsors
Jianbo Wu
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. The first unilateral thoracoscopic lobectomy was performed under general anesthesia 2. age 18- 80 years old 3. American Society of Anesthesiologists (ASA) physical status I-III 4. Sign the informed consent of the patients
Exclusion criteria
1. Moderate to severe obesity (i.e., BMI \> 30kg/m2) 2. Allergic or hypersensitive reaction to oxycodon 3. A history of chronic pain 4. Patients with significant heart, pulmonary, liver or renal disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The median effective dose | 3 minutes after remoal of the endotracheal tube, 30minutes after remoal of the endotracheal tube | The median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy |
Contacts
Primary ContactWu Jian bo, doctorate
Backup ContactZhang min, master
Outcome results
None listed