Primary Aldosteronism
Conditions
Brief summary
This study employs a prospective, single-center, open, observational research design to evaluate postoperative adrenal cortical function in patients with primary aldosteronism (PA) and to explore indicators predicting postoperative adrenal insufficiency and their predictive efficacy
Detailed description
Patients suspected of having primary aldosteronism and admitted for treatment, who are diagnosed with primary aldosteronism through at least one confirmatory test, and subsequently diagnosed with unilateral primary aldosteronism via bilateral adrenal vein sampling and ACTH stimulation test, will undergo surgery. Those who have an ACTH stimulation test within one week postoperatively will be included in the study. This study employs a prospective, single-center, open, observational research design to evaluate postoperative adrenal cortical function in patients with primary aldosteronism (PA) and to explore indicators predicting postoperative adrenal insufficiency and their predictive efficacy
Interventions
None listed
Sponsors
Ruijin Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients diagnosed with unilateral primary aldosteronism who undergo surgical treatment and have their cortical function assessed by an ACTH stimulation test within one week postoperatively.
Exclusion criteria
* Patients using medications that affect adrenal cortical function. * Patients with a history of adrenal surgery * Pregnant or breastfeeding women * Patients with severe underlying diseases (such as liver or kidney failure) that may affect adrenal cortical function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with baseline kidney function levels | 1day | Creatinine, blood urea nitrogen (BUN), and uric acid levels |
| Patients' hormone levels at 0 minutes and 120 minutes after postoperative ACTH stimulation test | 1day | cortisol and aldosterone levels |
| Number of Participants with baseline lipid metabolic levels | 1day | blood lipid levels |
| Patients' baseline glucose metabolic levels | 1day | 0-minute、30-minute、60-minute 、120-minute and 180-minute blood glucose levels after OGTT |
| Number of Participants with baseline electrolytes levels | 1day | sodium, potassium, chloride, calcium, and phosphorus ion levels |
| The gender and age of the participants | 1 day | age in years and sex (female or male) of patients |
| Participant's weight and height | 1 day | BMI(body mess index) in kg/m\^2= (weight in kg) /(height in m)\^2 |
| Patients' baseline hormone level | 1day | serum hormone level |
| Number of Participants with baseline glucose metabolic levels | 1 day | glucose metabolism, lipid metabolism, liver and kidney function, electrolytes, etc |
| Patients' hormone levels at 0 minutes and 120 minutes after preoperative ACTH stimulation test | 1day | cortisol and aldosterone levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with changes of lipid metabolic levels after surgical management | 1day | blood lipid levels |
| the changes of glucose metabolic levels after surgical management | 1day | 0-minute、30-minute、60-minute 、120-minute and 180-minute blood glucose levels after OGTT |
| Number of Participants with changes of kidney function levels after surgical management | 1 day | Creatinine, blood urea nitrogen (BUN), and uric acid levels |
| the changes of hormone levels after surgical management | 1day | cortisol and aldosterone serum hormone level |
Outcome results
None listed