Cancer, Genetic Predisposition, Whole Body Imaging
Conditions
Keywords
MRI, Whole Body MRI, Genetic Predisposition to Cancer
Brief summary
Whole-body magnetic resonance imaging (WB-MRI) is a non-ionizing imaging method that can provide WB coverage using essential imaging contrasts with the possibility to include sequences focusing in specific body-regions as needed per case. WB-MRI is increasingly being used for the management of cancer patients, especially metastatic ones. An integral part of WB-MRI is becoming whole-body diffusion-weighted MRI (WB-DWI) which is a non-invasive tool used for staging and response evaluation in oncologic practice. WB-DWI is an inherently noisy technique, resulting in it accounting for more than 50% of the acquisition time of conventional whole-body MRI studies with overall duration at least 1-hour. Reducing acquisition times, without compromising image or diagnostic quality would facilitate the wider adoption of clinical WBDWI, reducing costs, and improving the patient experience
Interventions
DEVICEEnhanced Diffusion Software
Application of specific sequences with the use of Enhanced Diffusion Software during Patient MRI
Sponsors
GE Healthcare
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years old; * Patients with diagnosis of multiple myeloma, lymphoma, lung, prostate, breast, colorectal and gynecologic cancers; * Patients with genetic syndromes responsible for an increased predisposition to neoplasms (e.g. Li Fraumeni syndrome); * Signed written informed consent to personal data treatment for research purposes
Exclusion criteria
* Age \<18 years old; * Refusal to sign the written informed consent to personal data treatment for research purposes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiologists' satisfaction of the quality of images | 18 months | Radiologists' satisfaction of the quality of images after applying noise reduction methods, in terms of mean overall response rate ≥4 at the questionnaires' items |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of the de-noised WB-MRI in detecting lesions | 18 months | Comparison of diagnostic accuracy for lesion detection after applying noise reduction methods with that of standard reference imaging modalities, |
| Diagnostic accuracy of the de-noised WB-MRI in detecting staging metastatic oncologic patients. | 18 months | Comparison of diagnostic accuracy for staging neoplasms according to the reference staging system with that of standard reference imaging modalities. |
Countries
Italy
Contacts
Primary ContactEvis Sala
Outcome results
None listed