Heart Failure
Conditions
Keywords
heart failure, decompensated
Brief summary
The main hypothesis is that autonomic dysfunction cannot improve among patients reaching end-stage heart failure. To evaluate this, patients admitted with acute decompensated heart failure in Bispebjerg hospital, and history one or more admissions with the same condition within the prior year, will undergo repeated brief heart monitoring (10 min). Baseline recordings (at admission) will be compared with equivalent measurements before discharge to explore whether heart rate variability increases. Patients will be followed for six months after discharge from the hospital.
Detailed description
If the patient accepts to participate and signed the project informed consent, their clinical record will be followed until the last patient included has been followed for six months.
Interventions
DIAGNOSTIC_TESTheart monitoring
individual comparison of heart rate variability at admission with a repeated measurement before discharge
Sponsors
University Hospital Bispebjerg and Frederiksberg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18-years age or older * admitted with acute decompensated heart failure for less than 48 h
Exclusion criteria
* pacemaker * not signed informed consent * other heart rhythm than sinus rhythm or atrial fibrillation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of rehospitalizations | up to six months after discharge from index admission | number of emergency rehospitalizations, classified according to: 1. new decompensation of heart failure 2. side effects / complications to therapy for heart failure 3. other |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate Variability change from admission to discharge | repeated measurement at baseline (within 48h from time of index admission) and before discharge (estimated one week on average from index admission) | Measurement of heart-rate oscillations over a short term (30 min) of continuous three-lead electrocardiogram recording divided into two time domains: Domain 10min: relaxed, supine position for 10 min Domain 30 min: comprising the first 10 min-domain in addition to stand-up and walking for 5 min, followed by sitting relaxed until completing 30 min recording in total |
Other
| Measure | Time frame | Description |
|---|---|---|
| Diastolic function | six months | Measurement of changes diastolic function in right and left ventricle based on wavelet-ECG measurements |
Countries
Denmark
Contacts
Primary ContactHelena Dominguez
Outcome results
None listed