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Unravelling the Interplay of Weight Stigma and Pregnancy Outcomes: A Prospective Cohort Study

Unravelling the Interplay of Weight Stigma and Pregnancy Outcomes: A Prospective Cohort Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06531694
Enrollment
800
Registered
2024-08-01
Start date
2026-06-01
Completion date
2028-12-01
Last updated
2026-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight and Obesity, Pregnancy Outcomes, Weight Stigma

Keywords

Prenatal care, Healthcare

Brief summary

The goal of this prospective cohort study is to investigate the contribution of stigma and discrimination due to body size to adverse pregnancy outcomes. We also aim to explore the role of psychological and social factors in this relationship. The specific objectives of this study are: Objective 1: Explore weight stigma as a mediator of the association between BMI ≥30 kg/m2 and adverse pregnancy outcomes. Objective 2: Explore confounding factors not previously considered such as weight cycling, trauma, eating disorders, and internalised weight bias as mediators in the relationship between obesity and adverse pregnancy outcomes.

Detailed description

The specific research questions for each objective are: Objective 1 RQ1.1: Does weight stigma experienced during pregnancy in a healthcare setting reported up to 34 weeks gestation mediate the association between pre-pregnancy obesity (BMI ≥30) and gestational diabetes mellitis (GDM) (primary outcome)? RQ1.2: Does weight stigma experienced during pregnancy in a healthcare setting reported up to 34 weeks gestation mediate the association between pre-pregnancy obesity (BMI ≥30) and (i) induction of labour; (iv) mode of birth; (ii) gestational hypertension (any); (iii) infant birth weight; and (iv) establishment of breastfeeding by 6 weeks postpartum (secondary outcomes)? Objective 2: RQ2.1: Do weight cycling, history of trauma, history of eating disorders, and internalised weight bias explain any of the variance in the mediation relationships described above?

Interventions

None listed

Sponsors

Monash University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Pregnant between 10-22 weeks' gestation * Greater or equal than 18 years of age * Booked to give birth at Adelaide Women's and Children's Hospital or Royal Women's and Children's Brisbane * Access to the Internet to complete the survey * Consents to the extraction of hospital electronic medical record data about the woman and relevant to the study. * Ability to read and understand English

Exclusion criteria

* Pregnant with multiple gestation * Insufficient English language skills to consent and complete the questionnaires.

Design outcomes

Primary

MeasureTime frameDescription
Proportion of women diagnosed with gestational diabetes mellitis by 34 weeks gestation34 weeksMeasuring the number of women reporting a diagnosis of gestational diabetes mellitis by 34 weeks gestation as assessed via self-reported measures and chart review.

Secondary

MeasureTime frameDescription
Proportion of women experiencing induction of labour6 weeks postpartumIdentifying whether the woman's labour was spontaneous or induced measured via a self-reported questionnaire.
Proportion of women reporting each mode of birth (i.e., vaginal birth, caesarean section, assisted vaginal birth, or other)6 weeks postpartumIdentifying the mode of birth assessed via a self-reported questionnaire. Options are: vaginal birth, caesarean section, assisted vaginal birth (e.g., with forceps), or other.
Proportion of women who reported experiencing gestational hypertension in their most recent pregnancy6 weeks postpartumIdentifying the proportion of women who reported a diagnosis of gestational hypertension during their most recent pregnancy via a self-reported questionnaire.
Infant birth weight (in grams) reported by mothers for their most recent infant6 weeks postpartumInfant birth weight (in grams) reported by mothers based on their most recent baby's birth certificate or hospital discharge summary information.
Proportion of women currently breastfeeding their infant reported by mothers at 6-weeks postpartum6 weeks postpartumThe proportion of women currently breastfeeding their infant (yes/no) reported by mothers at 6-weeks postpartum

Contacts

CONTACTBriony Hill, PhD
briony.hill@monash.edu+61421012283
CONTACTMegan Mitchell, PhD
megan.mitchell@adelaide.edu.au
PRINCIPAL_INVESTIGATORBriony Hill, PhD

Monash University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026