Kidney Cancer
Conditions
Keywords
Kidney cancer, Prediction model, Prognosis, Risk factors, Second primary malignancy
Brief summary
Second primary malignancy (SPM) significantly impacts the survival and prognosis of patients. This study endeavors to identify risk and prognostic factors associated with SPM after first primary kidney cancer and construct predictive nomograms.
Detailed description
In recent years, with the advancement of cancer treatment techniques and the prolonged survival of patients, the prevalence of Second primary malignancy (SPM) has been escalating, emerging as a significant health issue among cancer survivors. The goal of this study is to identify risk and prognostic factors associated with SPM after first primary kidney cancer and construct nomograms to provide clinical evidence. The main questions this study aims to answer are: (1) What are the risk factors associated with the prevalence of SPM after kidney cancer? (2) What are the prognostic factors associated with the overall survival (OS) of kidney cancer patients with SPM? (3) How to accurately predict the probability of developing SPM after kidney cancer and the OS of kidney cancer patients with SPM? In this retrospective population-based cohort study, Patients diagnosed with first primary kidney cancer between 2000 and 2020 were retrospectively enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Researchers will concentrate on the risk and prognostic factors of SPM after kidney cancer, and develop nomograms to forecast the development and overall survival (OS) of SPM after kidney cancer.
Interventions
PROCEDURESurgery, radiation therapy and chemotherapy
Surgery, radiation therapy and chemotherapy
Sponsors
Peking University First Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* (1) Diagnosed age was between 18 and 80 years old * (2) Diagnosed histologically confirmed as first primary kidney cancer * (3) The staging of kidney cancer was early or localized advanced (T1/2/3N0M0) * (4) Detailed survival data and follow-up information should be provided
Exclusion criteria
* (1) Histological conformation for diagnosis was unavailable * (2) The type of reporting source was Death certificate only or Autopsy only * (3) Patients with other malignancies before the diagnosis of primary kidney cancer * (4) The staging of kidney cancer was not early or localized advanced (T1/2/3N0M0) * (5) Diagnosis interval between first primary malignancy (FPM) and second primary malignancy (SPM) was less than 6 months * (6) The information was not complete
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Developing a second primary malignancy (SPM) | This time was calculated as the time interval from the diagnosis of first primary kidney cancer to the diagnosis of second primary malignancy, assessed up to 20 years. | This time was calculated as the time interval from the diagnosis of first primary kidney cancer to the diagnosis of second primary malignancy. |
| Overall survival (OS) | From the date of diagnosis of the second primary malignancy to the date of death from any cause or the data of last follow-up, whichever came first, assessed up to 20 years. | OS was calculated as the time interval from the diagnosis of the second primary malignancy to death or the time to the last follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cancer-specific survival (CSS) | From date of diagnosis of the second primary malignancy until the date of death from the same disease or the date of last follow-up, whichever came first, assessed up to 20 years. | CSS was calculated as the time interval from the diagnosis of the second primary malignancy to death from the same disease or the last follow-up. |
Countries
China
Outcome results
None listed