Bronchial Neoplasms, Cryotherapy Effect
Conditions
Keywords
cryobiopsy, cryotherapy, endobronchial tumors
Brief summary
This study was to assess the diagnostic yield and the safety of bronchoscopic cryotechniques in the management of endobronchial tumors.
Detailed description
Novel flexible cryoprobes were introduced for tissue sampling during bronchoscopy. Employing this approach, the sample is collected when frozen, with the tissue attached to the frozen end of the probe. This approach enables the retrieval of larger tissue samples from endobronchial lesionsEndobronchial cryotherapy is employed to treat individuals with obstructive central bronchial lung cancers. It has been demonstrated to effectively recanalize obstructed respiratory passages, alleviate symptoms, and improve the quality of life for patients in advanced stagesThis study aimed to assess the effectiveness and safety of using bronchoscopic cryotechniques for diagnosing and treating endobronchial malignancies.
Interventions
PROCEDUREEndobronchial cryobiopsy and cryotherapy using flexible bronchoscopy
Bronchoscopic evaluation of endobronchial lesion with biopsy and cryotherapy for recanalisation
Sponsors
Cairo University
Sohag University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with radiologically suspected endobronchial masses
Exclusion criteria
* Patients with contraindications to bronchoscopy. * uncorrected coagulopathy (if the international normalized ratio (INR) is more than 1.5). * severe refractory hypoxemia (even after administering the highest possible dose of oxygen, the partial pressure of oxygen (PaO2) stays below 70 mm Hg. * hypoventilation with hypercapnia (type 2 respiratory failure). * severe pulmonary hypertension \> 55 mmHg by echocardiography. * hemodynamic instability.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic yield | within 10 days | The recording of histopathological diagnosis as revealed by cryobiopsy |
| Recanalization Success | one day following the procedure | The measurement of degree of airway recanalization through bronchoscopic evaluation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Degree of dyspnea improvement after the procedure | 2 weeks after the procedure | Measurement of degree of dyspnea before and after the procedure using Modified medical research counsil scale for dyspnea (mMRC scale) |
Countries
Egypt
Outcome results
None listed