Chronic Diarrhea Owing to Underlying Microscopic Colitis

Chronic Diarrhea Owing to Underlying Microscopic Colitis: Diagnosis Challenges and Size of the Problem

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06530836

Enrollment

116

Registered

2024-07-31

Start date

2024-01-01

Completion date

2025-01-01

Last updated

2026-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Diarrhea, Microscopic Colitis

Brief summary

The goal of this observational study is to search for accurate diagnoses for patients with chronic diarrhea and assess the prevalence of microscopic colitis. The main question\[s\] it aims to answer \[is/are\]: Does microscopic colitis account for a significant portion of patients with chronic diarrhea? Participants will subjected to: * Routine laboratory examination. * Colonoscopy: A total colonoscopy will be done with visualization of the terminal ileum. Biopsies will be taken from each segment of the colon and any abnormal appearing areas, the right-sided colon (cecum, ascending colon, and transverse colon), the left-sided colon (descending colon and sigmoid colon), and the rectum.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with chronic watery diarrhea

Exclusion criteria

* Infectious colitis. * Inflammatory bowel diseases (ulcerative colitis, Crohn's disease, and indeterminate colitis). * Systemic disease associated with chronic diarrhea, e.g. Diabetes mellitus and Thyroid disease. * Drugs causing chronic diarrhea, e.g. antibiotics, antidepressants, and angiotensin-converting enzyme inhibitors. * Chronic diarrhea of decreased digestion as in pancreatic insufficiency and bile acid deficiency.

Design outcomes

Primary

Measure	Time frame	Description
Number of Participants with Chronic Diarrhea Diagnosed with Microscopic Colitis	6 weeks	Diagnostic criteria for the diagnosis of microscopic colitis include increased chronic inflammatory infiltration in the lamina propria, increased intraepithelial lymphocytes (IELs), degeneration of surface epithelium, and increased mitosis in crypts.

Secondary

Measure	Time frame	Description
Rate of Lymphocytic and Collagenous Types of Microscopic Colitis in Individuals Experiencing Chronic Diarrhea	2 weeks	Over 20 IELs per 100 inter-cryptal epithelial cells (normal \<1-5/100) were required for the diagnosis of lymphocytic colitis. For collagenous colitis, subepithelial collagen band thickness was measured by ocular micrometer in specimens stained with Masson's Trichrome. Specimen thickness over 10 μm was required for the diagnosis.

Countries

Egypt

Contacts

STUDY_DIRECTORAyman Sadek, MD

Associate Professor of Internal Medicine - Zagazig University

Outcome results