Anovulation, PCOS
Conditions
Keywords
Hirsutism, Normogonadotropic Anovulation, PCOS, androgenetic alopecia
Brief summary
The optimal cut-off value for diagnosing hirsutism in the modified Ferriman-Gallwey (mFG) point scale in the Polish population is not known. The correlation of mFG with the severity of androgenetic alopecia in the Ludwig scale (LS) is not known. The aim of the study is to determine the cut-off point for the diagnosis of hirsutism and to assess the correlation of the mFG scale score with the LS of androgenetic alopecia severity.
Detailed description
The aim of the study is to: * determine the cut-off point on the mFG scale, indicating hirsutism and to determine the correlation of the severity of androgenetic alopecia on the Ludwig scale with the mFG value in the population of women diagnosed and treated at the University Hospital in Krakow due to anovulation. * to determine the severity of hirsutism and the severity of androgenetic alopecia in individual PCOS phenotypes. Inclusion criteria are as follows: i) oligoovulation, i.e. menstrual cycles every \<21 days or \>35 days, ii) age 18-45 years Exclusion criteria: none To achieve the study objectives, the following will be performed: * Visual assessment of the severity of hirsutism on the modified Ferriman-Gallwey scale * Visual assessment of the severity of androgenetic alopecia on the Ludwig scale.
Interventions
DIAGNOSTIC_TESTAssessment of the severity of hirsutism using the visual modified Ferriman-Gallwey scale
Assessment of the severity of hirsutism using the visual modified Ferriman-Gallwey scale in 9 body regions rated from 0 (no growth of terminal hair) to 4 (extensive hair growth), thus with a score ranging from 0 (the lowest score - no hirsutism) to 36 points (the highest score - the greatest severity of hirsutism)
DIAGNOSTIC_TESTAssessment of the severity of endogenetic alopecia using the visual Ludwig Scale
Visual assessment of baldness on the Ludwig scale from I (least severe baldness) to III (most severe baldness): Type I - minimal thinning of the mid-line parting in the hair; Type II - gradual thinning and noticeable widening of the mid-line parting in the hair; Type III - Heavy to total thinning of the mid-line
Sponsors
Jagiellonian University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Inclusion criteria
* oligoovulation, i.e. menstrual cycles every \<21 days or \>35 days * age 18-45 years
Exclusion criteria
* virilizing tumors * congenital adrenal hyperplasia * ovarian hyperthecosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the severity of hirsutism in the PCOS and HPOD groups | up to 6 months | Comparison of the mFG score in the PCOS and HPOD groups; The modified Ferriman-Gallwey (mFG) scale assesses the severity of excessive hair growth on a scale of 0-4 points in 9 body regions (Upper lip, Chin, Chest, Upper back, Lower back, Upper abdomen, Lower abdomen, Upper arms, Thighs); the lowest possible score is 0 and the highest is 36; the higher the score, the greater the severity of excess hair |
| Comparison of the severity of endogenetic alopecia in the PCOS and HPOD groups | up to 6 months | Comparison of the LS score in the PCOS and HPOD groups; The Ludwig Scale (LS) assesses the severity of androgenetic alopecia on a scale from I to III, with additional sub-points within some of the above grades, i.e. I-1, I-2, I-3, I-4, II-1, II-2, III, IV (frontal - advanced); the higher the grade, the greater the severity of alopecia |
| Calculation of cut-off point for diagnosing hirsutism in the study population | up to 6 months | The cut-off point for diagnosing hirsutism will be calculated using the receiver operating characteristic curve |
| Assessment of diagnostic convergence of mFG and LS scales in diagnosing clinical hyperandrogenism | up to 6 months | The correlation of mFG and LS scale scores in the study population will be assessed using standard statistical methods |
Countries
Poland
Contacts
STUDY_CHAIRKazimierz Pityński, Prof.
Jagiellonian University
Outcome results
None listed