Diarrhoea
Conditions
Keywords
Stool, Diarrhoea, Paediatrics
Brief summary
Acute watery diarrhea is defined as the passage of 3 or more loose or liquid stools per day for 3 or more days but less than 14 days, including patients with mild to moderate dehydration per WHO classification. The study's outcome variables are stool frequency, measured by the total number of stools passed during 24 and 48 hours from the initiation of treatment, and hospital duration, measured by the total duration of hospital stay in hours. The null hypothesis states that racecadotril combined with standard treatment has no effect on reducing the mean number of stools passed during 48 hours compared to standard treatment alone in pediatric patients with acute watery diarrhea, while the alternate hypothesis suggests that racecadotril combined with standard treatment will significantly reduce the mean number of stools passed during 48 hours compared to standard treatment alone in these patients.
Interventions
DRUGRacecadotril
The intervention group will receive racecadotril+ORS+Zinc
Sponsors
Liaquat National Hospital & Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Months to 5 Years
Healthy volunteers
No
Inclusion criteria
* Hospitalized Patients with acute watery diarrhea of both genders who are 1. Age: 03 months to 05 years 2. Present in first 24 hours of onset of disease.
Exclusion criteria
<!-- --> 1. Parenteral Diarrhea 2. Chronic Diarrhea like Coeliac disease, Lactose intolerance 3. Mal-absorption Syndromes 4. Diarrhea related to food poisoning, dysentery as suggested by history 5. Severe dehydration patents who are vitally unstable. 6. Diarrhea associated with measles. 7. Persistent vomiting 8. Abdominal distention 9. Patients allergic to racecadotril 10. Patients managed before enrolled to study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stool frequency | 48 hours | Total no. of stools passed during 24 and 48 hours from initiation of treatment will be compared between two groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital Duration | 48 Hours | Total duration of hospital stay taken in hours |
Contacts
Primary ContactAqsa Jabeen Jabeen, MBBS
Outcome results
None listed