Blood Pressure
Conditions
Brief summary
The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is: The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff). Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.
Interventions
BEHAVIORALIsometric handgrip exercise
The participants will perform isometric handgrip exercises without blood flow restriction.
BEHAVIORALIsometric handgrip exercise with a narrow-elastic band
The participants will perform isometric handgrip exercises with blood flow restriction using a narrow-elastic band.
BEHAVIORALIsometric handgrip exercise with a wide-rigid cuff
The participants will perform isometric handgrip exercises with blood flow restriction using a wide-rigid cuff.
Sponsors
Hirofumi Tanaka
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
\- Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.
Exclusion criteria
* Abnormal clotting times * Acid-base imbalance/acidosis * Arterial calcification * Atherosclerotic vessels * Cardiopulmonary conditions * Diabetes * Dialysis/central venous access * General/local infection * High intracranial pressure * Hip, pelvis, or femur fracture * History of venous thromboembolism * Hypertension * Immobility for greater than 48 hours in the past month * Immobilizing cast * Implanted medical device * Lymphectomies * Obesity * Open fracture * Open or unhealed soft tissue injuries * Paralysis * Peripheral vascular disease * Pregnancy/postpartum * Prior revascularization * Renal compromise * Severe crush injuries * Sickle cell trait/anemia * Skin grafts * Stroke * Temporary nerve damage * Thrombophilia * Tumor/cancer * Varicose veins * Vascular grafting
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic blood pressure and diastolic blood pressure | 20 minutes | Beat-by-beat (both systolic and diastolic blood pressure) blood pressure before, during, and after exercise |
| Brachial artery diameter evaluated by an ultrasound machine | Before and 20 minutes after exercise | Brachial artery diameter will be measured by an ultrasound machine to calculate flow-mediated dilation (FMD) |
| Heart rate | 20 minutes | Monitor heart rate continuously before, during, and after exercise |
Countries
United States
Outcome results
None listed