Neurological Cancer
Conditions
Keywords
Acute toxicity, Late toxicity, Prediction models
Brief summary
Standardised evaluation of baseline data regarding tumor-, patient- and treatment-characteristics as well as follow-up data regarding tumor- and clinical-outcome of neuro-oncology patients treated with radical/curative radiotherapy. Motive: Currently there is limited data on dose-effect relationships of tissues and structures in and around the brain. This lack of knowledge hampers patient selection for proton therapy, technique innovations, and accurate prediction of treatment outcome. Goal: To evaluate the selection for radiation treatment, obtain more knowledge on dose-effect relationships and enable insight in necessary treatment technique innovations that would improve treatment outcome.
Interventions
OTHERRadiotherapy
Follow-up
Sponsors
University Medical Center Groningen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with neuro-oncological cancer * Patient receiving a radiotherapy dose XXX Gy
Exclusion criteria
* Failure to comply with any of the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Treatment associated CNS toxicity | Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy. | Treatment associated CNS Toxicity |
| Radionecrosis | Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy. | Treatment associated radionecrosos measured with CTCAE |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Progression free survival | Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy | Progression free survival |
| Overall survival | Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy. | Overall survival |
| Treatment associated non-CNS toxicity | Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy | Treatment associated non-CNS toxicity |
Other
| Measure | Time frame | Description |
|---|---|---|
| Patient-rated Quality of Life | Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy. | Patient-rated quality of Life is measured with the Quality-of-Life Questionnaire-C30 (EORTC QLQ-C30) |
| Cognition | Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy. | Patient-rated cognition is measured with the Groninger Cognitionlist (GroCo) |
Countries
Netherlands
Contacts
Primary ContactHiske vd Weide
Outcome results
None listed