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Removal of Erroneous Penicillin Allergy Labels: Implementation Study (REPeAL)

Removal of Erroneous Penicillin Allergy Labels: Implementation Study (REPeAL)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06528106
Acronym
REPeAL
Enrollment
30
Registered
2024-07-30
Start date
2024-06-18
Completion date
2025-06-30
Last updated
2024-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Penicillin Allergy

Brief summary

To test the implementation of penicillin allergy de-labelling delivered by the responsible clinical teams and the antimicrobial stewardship teams across all medical, surgical and critical care specialities in a UK hospital using the developed toolkit and a validated penicillin allergy decision support tool.

Detailed description

Aim: To test implementation of the penicillin allergy de-labelling complex intervention in surgical, medical and critical care patient pathway. Objectives: * To use the Institute for Health Improvement (IHI) Model for Improvement methodology to implement the penicillin allergy de-labelling complex intervention in each setting (surgery, medicine, critical care) * To measure the number of patients meeting inclusion criteria (\>16 with a penA not prescribed first line antibiotics) who have had their penicillin allergy record assessed by the wider clinical teams and separately by the AMS team. * To measure the patient uptake of penicillin allergy record removal (i.e. the rate of patient declining de-label / DOC). To interview 10-15 patients and 10-15 healthcare workers to gain insight into the penicillin allergy de labelling process.

Interventions

None listed

Sponsors

Royal Cornwall Hospitals Trust
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
OTHER

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years

Inclusion criteria

All adult (\>16) patients admitted to hospital over the study period with a penicillin allergy record preventing first line antibiotic use.

Exclusion criteria

None

Design outcomes

Primary

MeasureTime frame
The proportion of patients admitted to adult medical, surgical and critical care specialities with a penicillin allergy record, where the allergy record is preventing first line antibiotic therapy, that are safely de-labelled.1 year

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026