Bariatric Surgery, Erectile Dysfunction
Conditions
Keywords
bariatric surgery, erectile dysfunction, obesity
Brief summary
The prevalence of obesity has risen dramatically worldwide. Beyond its metabolic implications, obesity profoundly impacts sexual health, particularly in males, with erectile dysfunction emerging as a prevalent and distressing comorbidity. Studies show that bariatric surgery alleviates erectile dysfunction. Patients suffering from obesity have lower testosterone levels, which increase after weight-loss surgery. This study aims to investigate the relationship between erectile dysfunction improvement, weight loss and hormonal changes after surgery.
Detailed description
In recent decades, the prevalence of obesity has risen dramatically worldwide, presenting significant public health concerns. Beyond its metabolic implications, obesity profoundly impacts sexual health, particularly in males, with erectile dysfunction (ED) emerging as a prevalent and distressing comorbidity. Obesity exacerbates the risk of ED through complex interplays of physiological and psychological mechanisms. Physiologically, excess adiposity leads to chronic inflammation, endothelial dysfunction, and hormonal imbalances, all of which contribute to impaired vascular health and reduced testosterone levels, key factors in erectile function. Psychologically, body image dissatisfaction and decreased self-esteem associated with obesity can exacerbate sexual performance anxiety and further contribute to ED. Bariatric surgery is an established treatment method for long-term weight loss which also alleviates symptoms of diabetes, hypertension, and other weight-related comorbidities.
Interventions
PROCEDURESleeve gastrectomy
Each patient undergoes bariatric surgery. Each patient is diagnosed before surgery for erectile dysfunction. Similar tests are done 1 year after
Sponsors
Jagiellonian University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing laparoscopic sleeve gastrectomy who were qualified according to Guidelines of the International Federation for the Surgery of Obesity and Metabolic Disorders
Exclusion criteria
* lack of data during follow-up visit (at 1-year).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The International Index of Erectile Function score | immediately before surgery and one year after | 6 questions from IIEF official questionnare. Each question is score 1-5. Erectile dysfunction (ED) assessed using a validated tool Patient who scored \<25 points were considered for further analysis. Each patient was categorized into severity: 25-30 no ED, 19-24 mild ED, 13-18 mild to moderate ED, 7-12 moderate ED, 0-6 severe ED. After follow-up, patients with prior ED (\<25 IIEF) were assigned to three groups: 1 - no improvement, 2 - symptom alleviation (change in severity category), 3 - ED remission |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| percentage of excess weight loss (%EWL) | one year after surgery | Weight loss results |
| percentage of total weight loss (%TWL) | one year after surgery | Weight loss results |
| Testoreone (nmol/l) | immediately before surgery and one year after | Laboratory test using blood samples |
| Weight loss results | one year after surgery | weight loss (WL) in kg |
| Estradiol (pmol/l) | immediately before surgery and one year after | Laboratory test using blood samples |
| luteinizing hormone (mIU/ml) | immediately before surgery and one year after | Laboratory test using blood samples |
| Sex hormone binding (nmol/l) | immediately before surgery and one year after | Laboratory test using blood samples |
Countries
Poland
Outcome results
None listed