Perfusion, Peripheral Arterial Disease
Conditions
Brief summary
We investigate the peri-operative foot perfusion through dynamic contrast enhanced MRI in patients with peripheral artery disease
Interventions
DIAGNOSTIC_TESTDCE MRI
the recruited patients should complete pre- and post-operative DCE MRI workshops
Sponsors
Fudan University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 18 to 80 years old; * PAD patients with Fontaine grade II-IV or Rutherford grade 2-6 and underwent a successful revascularization; * Patients completed both pre- and post-operative MRI workups; * Patients signed the informed consent form and be able to complete the clinical follow-up for 1 months.
Exclusion criteria
* Patients has participated in other clinical studies; * Patients with Heart failure (NYHA III/IV)/right to left shunt heart disease/ severe aortic and mitral insufficiency/acute coronary syndrome/malignant arrhythmia/severe pulmonary hypertension (pulmonary artery pressure at least 90 mmHg)/moderate to severe renal insufficiency (creatinine clearance rate\<60 ml/min) * Any allergic constitution; * Pregnancy and childbirth; * Life expectancy\<12 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| preoperative perfusion parameters | Between Aug.1 2024 and OCT.31 2024 | preoperative perfusion parameters by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) |
Secondary
| Measure | Time frame |
|---|---|
| ankle brachial index | Between Aug.1 2024 and OCT.31 2024 |
| clinical success | Between Aug.1 2024 and NOV.30 2024 |
| survival | Between Aug.1 2024 and NOV.30 2024 |
Outcome results
None listed