Endovascular Procedures
Conditions
Keywords
acupoint stimulation, cerebral endovascular intervention, lactate
Brief summary
It is advocated that neuroprotection should be increased before endovascular treatment and that the penumbra should be protected from reperfusion damage after recanalization. Monitoring lactate and pH levels in acute ischemic stroke patients who have had endovascular recanalization can be utilized to predict mortality and morbidity, especially in the first five hours after the procedure. This study aims to observe the effect of acupoint stimulation on lactate level during endovascular recanalization.
Interventions
OTHERelectroacupuncture
electrical stimulation is given through needles inserted into the skin
OTHERsham needle
needles are inserted shallowly into the skin
Sponsors
Air Force Military Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥18 years * scheduled for cerebral endovascular intervention
Exclusion criteria
* American Society of Anesthesiologists status over level three * history of cerebral vascular intervention * history of severe neurological disease (stroke, neurological degenerative disease, psychiatric disease) * severe hepatic or renal dysfunction * severe glucose disorder or thyroid dysfunction * contraindications to transcutaneous electrical stimulation (infection or injury of the skin area, implanted electrical devices)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| arterial level of lactate at 30 minutes after recanalization | 30 minutes after recanalization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of serum brain-derived neurotrophic factor at 30 minutes after recanalization | 30 minutes after recanalization | — |
| Concentration of serum interleukin-6 at 30 minutes after recanalization | 30 minutes after recanalization | — |
| arterial level of lactate immediately after recanalization | about 1 minute after recanalization | — |
| pH value at 30 minutes after recanalization | 30 minutes after recanalization | — |
| Concentration of HCO3- at 30 minutes after recanalization | 30 minutes after recanalization | — |
| Concentration of base excess at 30 minutes after recanalization | 30 minutes after recanalization | — |
| partial pressure of oxygen at 30 minutes after recanalization | 30 minutes after recanalization | — |
| partial pressure of carbon dioxide at 30 minutes after recanalization | 30 minutes after recanalization | — |
| Concentration of serum tumor necrosis factor α at 30 minutes after recanalization | 30 minutes after recanalization | — |
| Concentration of HCO3- immediately after recanalization | about 1 minute after recanalization | — |
| Concentration of base excess immediately after recanalization | about 1 minute after recanalization | — |
| partial pressure of oxygen immediately after recanalization | about 1 minute after recanalization | — |
| partial pressure of carbon dioxide immediately after recanalization | about 1 minute after recanalization | — |
| score of modified Rankin's scale at 24 hours after recanalization | 24 hours after recanalization | the minimum and maximum values of modified Rankin's scale is 0 and 5, and higher scores mean a worse outcome. |
| incidence of stroke during hospitalization | From end of surgery to discharge from hospital, at an average of 5 days | — |
| Incidence of death during hospitalization | From end of surgery to discharge from hospital, at an average of 5 days | — |
| length of hospitalization | From end of surgery to discharge from hospital, at an average of 5 days | — |
| pH value immediately after recanalization | about 1 minute after recanalization | — |
Countries
China
Outcome results
None listed