Post Operative Pain
Conditions
Brief summary
It is proved that the addition of magnesium sulfate to local anesthetics for neuraxial anesthesia improves the quality of analgesia and prolongs the duration of anesthesia . In-vitro and in-vivo studies have demonstrated that magnesium enhances the local anesthetics effect on peripheral nerves . No previous studies were conducted on magnesium sulfate as an adjuvant to the local anesthetic in genicular nerve block. Hence, this study will be conducted to assess analgesic efficacy of magnesium sulfate when added to bupivacaine in ultrasound guided genicular nerve block
Interventions
PROCEDUREgenicular nerve block using bupivacaine and magnesium
The patients will receive 13 ml of 0.5% bupivacaine and 2 ml of 10% magnesium sulfate
PROCEDUREgenicular nerve block using bupivacaine and normal saline
The patients will receive 13 ml of 0.5% bupivacaine and 2 ml of normal saline
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologist (ASA) I or II physical status. * Between 18 and 70 years of age. * Both genders. * Patients undergoing total knee replacement surgery.
Exclusion criteria
* Patient refusal. * ASA Ⅲ and Ⅳ patients. * Known allergy to the study drugs. * Hypermagnesemia. * Central or peripheral neurological disease. * Pregnancy. * Drug or alcohol abuse. * Localized infection at the site of the block. * Bleeding disorder (platelets count less than 100,000 or international normalized ratio more than 1.4)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numerical Rating Scale | 24 hours post-operatively | Pain will be assessed with Numerical Rating Scale. Patients will be asked to circle the number between 0 and 10, that fits best to their pain intensity. Zero usually represents 'no pain at all' whereas the upper limit represents 'the worst pain ever possible. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| First request for analgesia | 24 hours post-operatively | — |
| Total opioid consumption | 24 hours post-operatively | — |
| Patient satisfaction | 24 hours post-operatively | Patient satisfaction will be assessed at 48 h postoperatively (0 = very dissatisfied, 2 = somewhat dissatisfied, 3 = somewhat satisfied, 4 = very satisfied) |
Countries
Egypt
Outcome results
None listed