Antibiotic Susceptibility in Symptomatic Benign Prostate Hyperplasia, Bacteriuria in Symptomatic Benign Prostate Hyperplasia, Treatment Response to Antibiotics in Symptomatic Benign Prostate Hyperplasia
Conditions
Keywords
Bacteriuria, Benign Prostate Hyperplasia, Urinary Tract Infection
Brief summary
The goal of this prospective observational study is to identify the common pathogens and antibiotic sensitivity pattern in urine samples of men with symptomatic BPH and to assess severity of LUTS in patients with symptomatic BPH using IPSS score before and after antibiotic therapy.
Detailed description
This was a hospital-based prospective observational study. All patients with symptomatic BPH attending the Urology Out-Patient Department (OPD) of the study site were enrolled. Informed and written consent was obtained from all participants. Demographic data were recorded, and detailed histories were taken regarding the duration and symptoms of BPH, including incomplete bladder emptying, frequency, intermittency, urgency, weak stream, straining, nocturia, and relevant past history. IPSS scoring was conducted. A thorough clinical examination, including general physical, systemic, and digital rectal examination, was performed. During the rectal examination, the prostate was checked for nodules, softness, induration, or tenderness. Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile.
Interventions
DRUGAntibiotic therapy
Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile. The patients were then prescribed antibiotics based on susceptibility testing for a duration of 1 week.
Sponsors
Tribhuvan University Teaching Hospital, Institute Of Medicine.
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with symptomatic BPH.
Exclusion criteria
* Patients with indwelling catheters * Recent antibiotic use * Immunocompromised states (e.g., HIV, HCV) * Uncontrolled diabetes mellitus (Hemoglobin A1c \> 7%) * Steroid therapy * Those who declined to provide consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of common pathogens and Antibiotic susceptibility testing | 4 weeks | Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile among symptomatic patients with BPH. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Severity of LUTS in patients with symptomatic BPH | 4 weeks | The study assess severity of LUTS in patients with symptomatic BPH using IPSS score before and after antibiotic therapy. |
Countries
Nepal
Outcome results
None listed