Gastro-entero-pancreatic Neoplasms
Conditions
Brief summary
Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.
Detailed description
Given the need for the use of experimental models that mimic the tumor of origin
Interventions
None listed
Sponsors
Regina Elena Cancer Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* over 18 years of age; * diagnosis of GEP-NEN carried out via histological investigation or via positivity to the uptake PET-CT with 68Ga-peptides; * availability of adequate material for the preparation of organoid cultures, derived from surgery; * written informed consent.
Exclusion criteria
* previous chemotherapy treatments
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Set up of at least 10 organoid cultures | 42 months | The organoids will be generated from tumor tissue samples and surrounding healthy tissue obtained from patients affected by GEP-NEN (who meet the inclusion/exclusion criteria) collected, according to clinical practice, during tumor resection surgery. Only the excess material after carrying out all the investigations necessary for the correct diagnosis histological analysis can be used for the purpose of the project |
Countries
Italy
Contacts
Primary ContactLaura Monteonofrio, Doctor
Outcome results
None listed