Small Intestine Bacterial Overgrowth
Conditions
Keywords
small intestine bacterial overgrowth, oral cecum transit time, abdominal distention
Brief summary
Most studies of bloating have focused on functional factors, while data on organic abdominal distention are rare, and studies that combine small intestine bacterial overgrowth and/or oral cecum transit time abnormalities are more urgent to explore. On this basis, patients with functional abdominal distension complicated with small intestine bacterial overgrowth were divided according to whether there was abnormal oral cecum transit time, and given the same treatment plan. The relief effect of abdominal distension, small intestine bacterial overgrowth turning negative and oral cecum transit time recovery were observed, so as to further clarify the cause of abdominal distension patients.
Detailed description
Part 1 Clinical characteristics of small intestinal bacterial overgrowth in patients with abdominal distension of different etiologies The clinical characteristics of small intestine bacterial overgrowth and oral cecum transit time in patients with abdominal distention of different etiology (organic and functional) were studied to lay a foundation for further exploration of treatment of functional abdominal distention. Part 2 Efficacy observation of functional abdominal distention combined with small intestine bacterial overgrowth To observe the effect of antibiotics on abdominal distension in patients with functional abdominal distension complicated with small intestine bacterial overgrowth, and observe the effect of rifaximin on small intestine bacterial overgrowth and oral cecum transit time, so as to provide new ideas for the diagnosis and treatment of abdominal distension patients.
Interventions
DRUGRifaximin
Both groups were treated with rifaximin for 14 days, during which follow-up records were reported by the subjects in the daily reference case report form. Methane and hydrogen breath tests were repeated 2 weeks after withdrawal.
Sponsors
Navy General Hospital, Beijing
Air Force Military Medical University, China
Beijing Tongren Hospital
Beijing Friendship Hospital
Beijing Chao Yang Hospital
Beijing Tiantan Hospital
The Luhe Teaching Hospital of the Capital Medical University
China-Japan Friendship Hospital
Beijing Aerospace General Hospital
Beijing Jishuitan Hospital
Peking University Third Hospital
Peking Union Medical College Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Part 1 Clinical characteristics of small intestinal bacterial overgrowth in patients with abdominal distension of different etiologies 1. Age 18-60 years old and gender; 2. The chief complaint is abdominal distension and/or abdominal distension, abdominal distension and/or abdominal distension more prominent than other symptoms. Part 2 Efficacy observation of functional abdominal distention combined with small intestine bacterial overgrowth 1. Patients with functional abdominal distension and small intestinal bacterial overgrowth were selected in Part 1; 2. No drug contraindications.
Exclusion criteria
Part 1 Clinical characteristics of small intestinal bacterial overgrowth in patients with abdominal distension of different etiologies 1. Preparation for pregnancy, pregnancy, breastfeeding women, or overall poor compliance, or other conditions that the investigator believes need to be excluded; 2. History of malignant tumors, history of abdominal surgeries; 3. Food intolerance, confirmed or suspected lactose intolerance; 4. Diagnosis of urinary system (chronic kidney disease, etc.), immune system (scleroderma, etc.), nervous system (Parkinson's disease, etc.), mental system (depression, etc.) and other diseases outside the digestive system; 5. Antibiotics and microecological preparations should be used within two weeks. Use motility enhancers, secretagogues, antifoaming agents, spasmolytics, opioids, antidepressants and other medications within a week. Part 2 Efficacy observation of functional abdominal distention combined with small intestine bacterial overgrowth 1. Antibiotics and microecological preparations should be used within two weeks; 2. Use motility enhancers, secretagogues, antifoaming agents, spasmolytics, opioids, antidepressants and other medications within a week.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Part 2 Negative conversion rate of small intestinal bacterial overgrowth and oral cecum transit time | 2 weeks | 1. Negative conversion rate of small intestinal bacterial overgrowth (%) =Number of small intestinal bacterial overgrowth negative after treatment/ Number of functional abdominal distention in Part 2\*100% 2. Negative conversion rate of oral cecum transit time (%) =Number of oral cecum transit time normal after treatment/ Number of experimental in Part 2\*100% |
| Part 1 Positive rate of small intestinal bacterial overgrowth | 1 day | Positive rate of small intestinal bacterial overgrowth in organic and functional abdominal distension |
| Part 1 Abnormal rate of oral cecum transit time | 1 day | Abnormal rate of oral cecum transit time in organic and functional abdominal distension |
| Part 2 Effective rate of abdominal distension | 2 weeks | Total effective rate (%) = Obvious effective rate (%) + Effective rate (%) 1. Obvious effect: the degree and frequency of abdominal distension score improved, or even completely disappeared, small intestinal bacterial overgrowth negative 2. Effective: the degree and frequency of abdominal distension score improved, small intestinal bacterial overgrowth positive 3. Ineffective: the degree and frequency of abdominal distension score did not improve |
Contacts
Primary ContactJing-Nan Li, MD,Ph.D
Outcome results
None listed