Chemotherapy Effect, Childhood Cancer, Dental Caries, Malocclusion, Tooth Defect
Conditions
Keywords
Childhood cancer survivors, Dental defect
Brief summary
To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors. Having such a method at our disposal would enable us to better assess the risk to develop those defects and will help us provide new prevention and treatment strategies to ensure a healthy oral development. The aims of this study are : * Assess the caries risk in childhood cancer survivors compared with a control group. * Assess the dental development defects risk in childhood cancer survivors compared with a control group.
Detailed description
This will be an international study comparing the Childhood Cancer Survivors (CCS) and a control group. A questionnaire will be provided to the patients to gather information. A standard of care dental examination will then take place in a dental office in the Cliniques Universitaires Saint-Luc. We also collect medical data to complete the files.
Interventions
DIAGNOSTIC_TESTClinical and radiographic dental examination
complete clinical oral examination + intra-oral and panoramic x-rays
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Interventionnal study, cohort study
Eligibility
Sex/Gender
ALL
Age
12 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* age below 10 at cancer diagnosis (for the CCS group). * Chemotherapy must have been used to treat the patient (For the CCS group). * The patient is 12 years old or older at the time of the follow-up appointment of the present study
Exclusion criteria
* A patient who was diagnosed and treated after 10 years old. * Patient below 12 years old at time of study recruitment * Patients with syndrome or diseases that involve teeth impairment\* * Pregnant patient * Refusal or inaptitude to undergo dental and radiographic examination
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of the caries experience by using the Decay Missing Filled Teeth score (DMFT) | Thoughout the entire study, approximately during 2 years | Assess the impact of the chemotherapy agents on the risk of ulterior caries development |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of the prevalence of dental development defects (DDD) | Thoughout the entire study, approximately during 2 years | Assess the impact of the chemotherapy agents on the risk of ulterior dental development defect |
Countries
Belgium
Contacts
Primary ContactArmand IRAKOZE
Outcome results
None listed