Pulmonary Complications in Elderly Patients

Effect of Protective Lung Ventilation Measures on Pulmonary Complications in Elderly Patients After Upper Abdominal Laparoscopy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06517550

Enrollment

136

Registered

2024-07-24

Start date

2024-10-01

Completion date

2025-11-01

Last updated

2026-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Complications

Brief summary

The incidence of postoperative pulmonary complications in elderly patients undergoing upper abdominal laparoscopic surgery remains high, and the lung protective mechanical ventilation strategy aims to reduce the incidence of lung injury caused by ventilators. PEEP, as an important protective ventilation strategy, maintains end expiratory alveolar volume to improve intraoperative oxygenation and pulmonary respiratory mechanics, and plays a protective role in the lungs; Personalized PEEP is the most beneficial, especially for elderly patients. However, there is currently no ideal way to achieve precise and personalized regulation of PEEP. This project aims to target and control intraoperative mechanical ventilation to drive pressure, personalize PEEP titration, and conduct a randomized controlled study on perioperative changes in pulmonary oxygenation function and pulmonary complications in elderly patients undergoing upper abdominal laparoscopy.

Interventions

OTHERpositive end-expiratory pressure while mechanical ventilation

a parameter in ventilator

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

60 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* ASA\<III、 general anesthesia, 60-80 years, BMI\<30kg/m2, pneumoperitoneum time\>0.5h, laparoscopic surgery on the upper abdomen (stomach, liver, gallbladder)

Exclusion criteria

* Severe anemia (Hb\<60g/L), OSA, severe COPD (FEV1\<30% pre), asthma, bronchiectasis, preoperative pulmonary infection, respiratory failure, thoracic deformity, postoperative return to ICU, heart function grade III-IV, severe liver and kidney dysfunction (Child B or C, dialysis), intraoperative bleeding greater than 30% of blood volume.

Design outcomes

Primary

Measure	Time frame	Description
the changes of oxygenation index	pre-surgery, leave-PACU, one-day after surgery and 7-day after surgery	The patients' changes of Oxygenation index when leave-PACU, one-day after surgery and 7-day after surgery compared with pre-sugery oxygenation index

Secondary

Measure	Time frame	Description
Incidence of pulmonary complications	30 and 90 days after surgery	Incidence of pulmonary complications at 30 and 90 days after surgery

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026