Early Esophageal Cancer
Conditions
Brief summary
With the development of endoscopy, more and more patients with superficial esophageal squamous cell carcinoma (ESCC) receive endoscopic resection rather than traditional surgery. However, there is still no complete consensus on the risk factors for lymph node metastasis (LNM) and recurrence of ESCC after endoscopic resection. The existing curative resection criteria are strict to a certain extent, and a considerable number of patients are overtreated according to the current standard of additional treatment. Thus, we aim to conduct a multi-center retrospective and prospective study to construct a large cohort of ESCC based on the previously established multi-center collaborative research network and clinical big data, analyze the risk factors of LNM and recurrence in patients with early esophageal squamous cell carcinoma after ESD, establish an accurate and simple risk prediction model, and evaluate the discrimination efficiency of this model.
Interventions
OTHERobservational study
observational study, no intervention
Sponsors
Lianshui People's Hospital
The second affiliated hospital of Xuzhou medical university
The second people's hospital of Nanyang
Nanchong Central Hospital
Tongliao City Hospital
Yancheng First People's Hospital
The Second Hospital of Hebei Medical University
The Second Affiliated Hospital of Baotou Medical College
Affiliated Hospital of Southwest Medical University
Sichuan Cancer Hospital and Research Institute
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Zhongda Hospital
The First Affiliated Hospital with Nanjing Medical University
West China Hospital
The First Affiliated Hospital of Soochow University
Jiangsu Province Hospital of Traditional Chinese Medicine
Shandong Provincial Hospital
Shanxi Provincial People's Hospital
Henan Provincial People's Hospital
Anyang Cancer Hospital
Changhai Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Men and women, aged 18-85. 2. ESD was performed for early (superficial) esophageal squamous cell carcinoma, and the indication was in line with domestic and foreign guidelines. 3. The pathological stage after ESD was pT1a/pT1b. 4. The effective follow-up time after ESD was ≥3 years, or recurrence or LNM occurred during the follow-up period.
Exclusion criteria
1. Esophageal chemoradiotherapy or esophageal surgery were performed before ESD. 2. There is a history of carcinoma, early carcinoma, adenoma and other benign and malignant tumors of stomach and duodenum. 3. Pathological data after ESD were incomplete. 4. Combined with malignant tumors of other organs. 5. Fragmented endoscopic mucosal resection (EMR), multi-loop mucosal resection (MBM) and other endoscopic non-monolithic resection techniques were used. 6. New squamous cell carcinoma in other parts of esophagus during follow-up (metachronous carcinoma).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Noncurative Resection | 2022-12 Complete the preliminary clinical study preparation. 2023-10 Complete patient data analysis and sorting. 2024-10 Construct an accurate evaluation system. 2025-10 Conduct validation analysis of the evaluation system. | Noncurative resection was defined as the presence of residual tumor or lymph node metastasis at the vertical margin of the lesion confirmed by pathology after surgery, or local recurrence, lymph node metastasis, or distant metastasis attributable to the primary tumor during follow-up. |
Countries
China
Contacts
Primary ContactLuowei Wang, Doctor
Outcome results
None listed