Lung Inflammation, Lung Injury
Conditions
Brief summary
The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.
Detailed description
Patients who meet the inclusion criteria will be numbered in the order of admission, and a dedicated person will prepare codes and opaque envelopes for random allocation. This study was divided into 3 groups, one groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side, the other groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side; the other groups was ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side.
Interventions
PROCEDUREAdopting different ventilation modes during the operation
The ventilation side adopts different ventilation modes combined with continuous positive pressure ventilation on the surgical side.
Sponsors
Mao Enting
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
The researchers in this study enrolled suitable patients using a random number table method before surgery, and then performed different intraoperative single lung ventilation modes according to the grouping after unblinding the patients upon entering the room. The postoperative follow-up personnel or data analysts are unaware of the grouping status.
Intervention model description
This study was divided into 3 groups, one groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side, the other groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side; the other groups was ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side.
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Comprehensive examination and analysis of imaging, laboratory examination and other comprehensive examinations, the diagnosis is clear, which is in line with lobe resection surgical indications Age 18-75 years old, the gender is not limited; ASA grading Ⅰ \ III level; It is expected that the single lung ventilation time is ≥1 hours, and ≤3 hours
Exclusion criteria
Emergency surgery; There is a taboos on the existence of systemic anesthesia; There is a history of acute chronic upper respiratory infections in the past January; Previous bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation, phthisis ,aspergillosis , acute respiratory distress syndrome or history of respiratory failure; Merge the function of important organs such as heart, liver, and kidney; There was a history of chest surgery and the history of trauma; Preoperative lung function test obvious abnormal abnormal abnormalities (1 second of exhalation (FEV1) \<60%); Patients refuse to participate in the clinical trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Pulmonary Infection Score | Within 15 days after surgery | The clinical pulmonary infection score index is mainly used to evaluate the severity of pulmonary infection, which involves many factors, including: body temperature, white blood cell count, tracheal secretions, oxygenation, X-ray chest X-ray, and the progress of pulmonary infiltrates. The maximum score is 12 points, and the severity of infection is directly proportional to its score. |
Countries
China
Contacts
Primary ContactMao Enting
Outcome results
None listed