Portal Vein Thrombosis
Conditions
Brief summary
The goal of this observational study is to investigate the correlation between portal vein thrombosis (PVT) and the prognosis of liver transplantation. The main questions it aims to address are: What is the prevalence of PVT? What are the risk factors associated with PVT? What is the prognostic impact of preoperative PVT on liver transplantation? Participants are divided into two groups: the PVT group and the non-PVT group. The investigators will comparatively analyze the data of both groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, and clarify the prognostic effects of PVT.
Detailed description
The investigators aim to investigate the prevalence and risk factors of PVT, to develop a novel grading or rating system for PVT, and to explore the prognostic impact of preoperative PVT in liver transplantation. The investigators will: Recruit patients according to the inclusion/exclusion criteria and obtain signed informed consents. They will collect demographic and laboratory characteristics and classify patients into the PVT group and the non-PVT group based on preoperative ultrasound and/or computed tomography. Collect patients' perioperative medical imaging, surgical procedures, pathology reports, postoperative treatments, follow-up data, and clinical endpoints. Comparatively analyze the data of the PVT and non-PVT groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, clarify the prognostic effects of PVT, and propose a grading/rating system for PVT.
Interventions
OTHERObservation
No intervention were made.
Sponsors
Ru-zhou Cai
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Liver transplantation recipients 2. Aged 18 years or older.
Exclusion criteria
1. Retransplantation 2. Multi-organ transplantation 3. Portal vein tumor thrombus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Death | 10 years | Rate of death from various causes after liver transplant |
| Postoperative portal vein thrombosis | 10 years | Number of participants with portal vein thrombosis after liver transplant |
| Postoperative portal vein stenosis | 10 years | Number of participants with portal vein stenosis after liver transplant |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative complications | 1 year | Rate of re-surgery, interventional operation, endoscopy, dialysis, etc. |
Countries
China
Contacts
Primary ContactRu-zhou Cai, M.D.
Outcome results
None listed