Post Induction Hypotension
Conditions
Keywords
hypotension
Brief summary
The purpose of this study is to determine if lower extremity elevation (LEE) will reduce the incidence of postinduction hypotension, to compare the utilization of vasoactive medications after induction in patients with LEE and patients without LEE and to determine if LEE will increase measured cardiac output
Interventions
PROCEDUREGroup 1: LEE
Patients will be in supine position during induction with a 12" wedge placed at the level of the Achilles tendon (LEE)
Sponsors
The University of Texas Health Science Center, Houston
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists (ASA)3 or lower * Patients requiring general anesthesia
Exclusion criteria
* Allergic reaction to drugs commonly used for general anesthesia including fentanyl, midazolam, propofol, ephedrine and phenylephrine * Pregnant women * Requiring rapid sequence induction * Prisoners * Patient refusal * Emergency Surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants that demonstrate hypotension | From start of anesthesia upto institution of positive pressure ventilation (about 5 minutes) | Hypotension is defined as the reduction in mean arterial pressure by 20% or greater comparing the blood pressure measured before induction of anesthesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants that demonstrate Nadir blood pressure | From start of anesthesia upto institution of positive pressure ventilation (about 5 minutes) | Nadir blood pressure is the lowest value of blood pressure (BP) that can occur |
| Change in heart rate | From start of anesthesia upto institution of positive pressure ventilation (about 5 minutes) | — |
| Number of participants that need rescue vasoactive agents | From start of anesthesia upto institution of positive pressure ventilation (about 5 minutes) | — |
| Accumulated dose of rescue vasoactive agents | End of study (within 15 minutes of baseline) | — |
| Change in non-invasive cardiac output | From start of anesthesia upto institution of positive pressure ventilation (about 5 minutes) | — |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORRanganathan Govindaraj, MD
The University of Texas Health Science Center, Houston
Outcome results
None listed