Crohn Disease
Conditions
Keywords
perforation, biologic therapy, ileostomy
Brief summary
crohn's disease patients who present by intestinal perforation as the first presentation are hard to deal with. Surgical techniques as anastmosis or diversion stoma and active course of the disease may greatly affect the quality of life. In post-operative period, is the priority to avoid the post operative complications and to improve surgical outcomes or to stop active course of the disease and to induce remission?. So, those patients were classified into two groups. one group received biological therapy early post operative and the other group received it 2 or 3 months later after surgery and the investigators will compare results between the two groups.
Interventions
BIOLOGICALearly biologic therapy
biologic therapy for perforated Crohn's disease in the early postoperative period
BIOLOGICALlate biologic therapy
no biologic therapy for perforated Crohn's disease up to 2 to3 months in the post operative period
Sponsors
Zagazig University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients at or above 18 years old * patients with perforated bowel diagnosed as Crohn's disease at presentation underwent surgery
Exclusion criteria
* patients less than 18 years old * well known Crohn's disease patients on medical treatment * associated bowel disease as malignancy and diverticulosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| size of intra-abdominal fluids or collection | from the first post-operative day to 2 months postoperatively | size of peritoneal fluids will be measured by surface area in centimeter square ( weight x height) using ultrasound |
| bowel function | from the first post-operative day to 2 months postoperatively | bowel function will be assessed by hearing intestinal sound using Stethoscope |
| fecal fistula | from the first post-operative day to 2 months postoperatively | if found, its amount will be calculated per day using calibrated colostomy bag |
| skin maceration | from the first post-operative day to 2 months postoperatively | skin maceration surface area will be calculated by (weight x height) in centimeter square using a ruler |
| body weight | from the first post-operative day to 2 months postoperatively | weight gain or weight loss will be measured in kg |
| age | 2 hours before surgery | age in years will be recorded |
| sex | 2 hours before surgery | sex of patients (male or female) will be recorded |
Countries
Egypt
Outcome results
None listed