Stroke, Ischemic
Conditions
Brief summary
Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW). The efficacy and safety of EVT beyond the 24-hour window remain uncertain.
Interventions
OTHEREndovascular Therapy
Endovascular therapy, as an adjunct to standard stroke therapy, may be beneficial for a very select population of patients who present with an acute ischemic stroke and have a proven large, proximal occlusion on imaging. Endovascular therapy includes any one or more of the following: Intra-arterial thrombolytic therapy, aspiration, stent retrieval, or a combination of multiple mechanical devices.
Sponsors
Tianjin Huanhu Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Inclusion criteria
1. age≥18 years.; 2. blockage in the vertebrobasilar artery, including the vertebral artery or basilar artery, determined using computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/digital subtraction angiography (DSA); 3. VBAO occurrence more than 24 hours from LKW; 4. none to mild premorbid disability defined by modified Rankin Scale (mRS) score ≤2; 5. informed consent before enrollment in the clinical trials.
Exclusion criteria
1. neuroimaging evidence of cerebral hemorrhage on presentation; 2. lack of follow up information on outcomes at 90 days 3. serious, advanced, or terminal illness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days | 90(±14)days | A 0-6 scale running from perfect health without symptoms to death. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| distribution of patients with Modified ranking scale (mRS) (0-3) at 90 days | 90(±14)days | A 0-6 scale running from perfect health without symptoms to death. |
| Mortality within 90 days | 90(±14)days | mortality of any causes. |
| Incidence of symptomatic intracranial haemorrhage | 90(±14)days | Symptomatic intracranial hemorrhage was characterized as any type of intracranial hemorrhage observed on follow-up imaging between 22 and 36 hours and 7 days after stroke onset, accompanied by an increase of at least 4 points on the NIHSS from baseline or the lowest value within 7 days, or resulting in mortality. |
Countries
China
Outcome results
None listed