Intervention
Conditions
Brief summary
This study aims to assess the effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars with Necrotic Pulps.
Interventions
OTHERCalcium Hypochlorite as Root Canal Irrigant
Calcium Hypochlorite used as root canal irrigant during chemo-mechanical preparation
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
1. Systematically healthy patient (ASA I, II). 2. Age between 20 and 55 years 3. Male or female. 4. Mandibular premolar teeth having single canals diagnosed with pulp necrosis with asymptomatic apical periodontitis. 5. Radiographic examination using Digora intraoral periapical sensor plate and software showing mandibular premolars with (0-2 mm) periapical radiolucency.
Exclusion criteria
1. Medically compromised patients having significant systemic disorders. (ASA III or IV). 2. History of intolerance to NSAIDS. 3. Teeth with: * Immature roots * Vital pulp tissues. * Association with swelling. * Acute peri-apical abscess or acute exacerbation of a chronic abscess. * Mobility Grade II or III. * Previously accessed or endodontically treated * Deep periodontal pockets more than 4 mm * Vertical root fractures, coronal perforation, calcification, and external or internal root resorptions. 4. Patients who could not interpret the NRS. 5. Patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women were, also, excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain in Mandibular Premolars with Necrotic Pulps. | measured at 6, 12, 24, 48 hours after single visit treatment | measuring tool: Numerical Rating Scale (NRS). Unite of measurement: Categorical None 0 Mild 1-3 Moderate 4-6 Severe 7-10 Time of measurements: At 6, 12, 24, 48- hours post-treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Bacterial Reduction in Mandibular Premolars with Necrotic Pulps. | T0=Baseline immediate after access preparation . T1=Post-instrumentation. T1(within an hour) | Intracanal bacterial load reduction will be determined by bacterial counting using agar culture technique after root canal preparation (CFUs/ml), The growth will be semi quantitatively determined as very heavy, heavy, moderate, sparse and very sparse depending on the CFU ranging from \>100,000,˂100,000,˂10,000,˂1,000, ˂100 colony forming unit per 1 ml BHI respectively. |
| Number of analgesic tablets taken by the patient after endodontic treatment | Up to 48 hours postoperative. | Number of analgesic tablets taken by the patient after endodontic treatment Up to 48 hours postoperative. Measuring tool: counting Measurment unite: numerical. |
Contacts
Primary ContactYoumna Yassen Youmna Yassen, pds
Outcome results
None listed