CPK Levels After LC and Association With Analgesic Modalities

Does Postoperative Analgesic Modalities Effect Blood Creatin Phosphokinase Levels After Laparoscopic Cholecystectomy Surgery?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06508177

Enrollment

Registered

2024-07-18

Start date

2024-08-05

Completion date

2025-03-30

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myotoxicity

Keywords

creatine phosphokinase, cholecystectomy, interfascial plane blocks

Brief summary

Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

Detailed description

During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.

Interventions

OTHERİnterfascial plane block

Interfascial plane blocks will be added to the routine analgesia plan as part of multimodal analgesia.

OTHERStandart analgesia plan

This is the routine analgesia plan applied in our clinic.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ASA 1-3 * Laparoscopic cholecystectomy * under General Anesthesia

Exclusion criteria

* Morbidly obesity or cachexia * local anesthetic allergies * myopathies * coagulopathies * Obstructive sleep apne syndrome * hearth diseases * liver diseases * kidney diseases * thyroid-parathyriod dieseas * hiperlipidemias using Statins(HMG-CoA reductase inhibitors) * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
CPK levels	at postoperative 24th hour	Serum creatine phosphokinase levels at 24th hour

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026