Colonic Diverticuar Disease, Constipation, Defecatory Functions, Fecal Incontinence
Conditions
Keywords
defecatory function, anterior resection syndrome, constipation, diverticular disease, fecal incontinence, fragmented evacuation
Brief summary
This is a prospective randomized study aimed to verifying the short and long-term results of inferior mesenteric artery preservation following colorectal resection for diverticular disease
Detailed description
This study wants to demonstrate that the preservation of the inferior mesenteric artery allow to improve postoperative defecatory function and improve patient's quality of life.
Interventions
PROCEDUREIMA preserving
Performing left hemicolectomy, sigmoidectomy or rectal resection the IMA was preserved ligating the sigmoids arteries close to the colonic wall
PROCEDUREIMA sectioning
Performing left emicolectomy, sigmoidectomy or rectal resection the IMA is sectioned after the origin of left colic artery.
Sponsors
University of Roma La Sapienza
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* BMI < 35 * ASA I-III * Hinchey I-III
Exclusion criteria
* BMI > 35 * ASA IV * Hinchey IV * Previous procedures that could have been modified the nervous mesenteric pattern (surgery, radiotherapy or chemotherapy)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Defecatory disorders | 6 months from surgery | the presence of defecatory disorders was evaluated (Costipation, Evacuation frequency,evacuation urgency, fragmented evacuation,flatus incontinence, liquid incontinence) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Constipation | 6 months from surgery | The incidence and severity of postoperative constipation was evaluated with Cleveland Clinic Constipation Score ( score range from 0 to 30, the higher score defines worse constipation status) |
| Incontinence | 6 months from surgery | The presence of fecal incontinence was evaluated with Cleveland Clinic Incontinence Score( score range from 0 to 20, the higher score defines worse symptoms) |
| Anorectal Muscles function | 6 months from surgery | The anorectal muscles function was evaluated with anorectal manometry( sphincter lenght, maximum squeeze pression, resting anal pressure, squeeze duration, maximum pressure sustained) |
| Postoperative quality of life | 6 months from surgery | the postoperative QOL(quality of life) was evaluated with EORTC-30 tests( European organization for research and treatment of cancer, scores range from 0 to 100; a higher score represents a higher (better) level of functioning, or a higher (worse) level of symptoms) |
| Postoperative surgical complication | 1 month from surgery | The incidence of postoperative surgical complications was evaluated |
Outcome results
None listed