Metabolic Dysfunction-associated Steatotic Liver Disease
Conditions
Keywords
metabolic dysfunction-associated steatotic liver disease, MASLD, physical activity, myosteatosis, magnetic resonance imaging, magnetic resonance specroscopy, muscle biopsy
Brief summary
Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.
Detailed description
In this monocenter interventional study, we will assess the impact of physical activity on muscle fat content and liver disease severity in MASLD as well as the mechanisms mediating the potential beneficial effects of exercise.
Interventions
OTHERHigh-intensity interval training
High-intensity interval training
Moderate intensity exercise training
Low intensity exercise training
Sponsors
Concerted Research Action
Fonds National de la Recherche Scientifique
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patients presenting both MASLD and an excessive muscle lipid content (myosteatosis) assessed by magnetic resonance imaging will be recruited. All patients will then be randomized in three groups corresponding to three physical activity programs of increasing intensity.
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* confirmed MASLD at abdominal imaging * confirmed excessive muscle lipid content at imaging * stable weight
Exclusion criteria
* severe comorbidities including active malignancies, neuromuscular degenerative diseases * contraindications to physical activity * excessive alcohol consumption
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the impact of physical activity on muscle and liver phenotypes | every four weeks from baseline till study completion | the investigators will assess at baseline and every four weeks till study completion the impact of intervention on liver phenotype assessed by transient elastography and muscle phenotype assessed by MRI |
Countries
Belgium
Contacts
Primary ContactGuillaume Henin, MD, PhD student
Backup ContactNicolas Lanthier, MD, PhD
Outcome results
None listed