Sleep Disorder, Subjective Tinnitus
Conditions
Keywords
chronic subjective tinnitus, music therapy, cognitive behavioral therapy, neural mechanism
Brief summary
This study retrospectively analyzed the first and second visit data of chronic subjective tinnitus patients who received music combined with cognitive behavioral therapy in our hospital in recent years. Behavioral tests and tinnitus questionnaires, as well as sleep and depression scores, were used to analyze the therapeutic effects of this approach. EEG results were analyzed as a potential neurobiological marker to explore the neural mechanism of tinnitus symptom improvement.
Detailed description
The subjects of this study were chronic subjective tinnitus patients and normal controls who were treated with music therapy combined with cognitive behavioral therapy (music-CBT) in the Department of Otolaryngology of Sun Yat-sen Memorial Hospital from December 2016 to March 2024 and who had completed re-examination. The pre- and post-music-CBT data of past patients who met our study conditions were collected for retrospective statistics. The complete sample data included medical history, pure tone audiometry, tinnitus matching, tinnitus questionnaires (Tinnitus Handicap Inventory, Visual Analog Scales, tinnitus Functional Index), sleep quality questionnaire (Pittsburgh Sleep Quality Index), and depression questionnaire (Hamilton Depression Scale -24 items). The resting state electroencephalogram (rs-EEG). Retrospective statistical analysis was conducted to determine the clinical efficacy and influencing factors of music-CBT for chronic subjective tinnitus at 3 months and long term. Finally, the neural mechanism of music-CBT for tinnitus treatment was analyzed based on rs-EEG results.
Interventions
BEHAVIORALmusic-CBT
notched relaxation music combined with personalized CBT
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* adults aged between 18 and 60 * a total score of 18 or higher on THI * a constant tinnitus that can be matched * right-handed * no significant medical or psychiatric conditions
Exclusion criteria
* intermittent, pulsating or objective tinnitus * central nervous system disease * cognitive impairment * other contraindications for EEG testing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG functional connectivity and brain network characteristics | the exact 1 day of the first visit and review visit, within 3 - 4.5 months | EEG signals were used to explore the activation of brain regions and remodeling of poor connections in the postoperative outcomes of conductive hearing loss patients accompanied by with tinnitus. Power spectral density calculation, traceability analysis, functional connection, microstate, clustering coefficient, feature path length, feature path intermediation, and isocompatibility coefficient were collected and then analyzed. |
| tinnitus loudness | the exact 1 day of the first visit and review visit, within 3 - 4.5 months | Tinnitus loudness was calculated by the matched intensity subtracting the pure tone threshold at that frequency. |
| tinnitus handicap inventory (THI) | the exact 1 day of the first visit and review visit, within 3 - 4.5 months | There were 25 items in the THI scale, divided into three subscales (functional, emotional, and catastrophic), and response choices consisted of no (0 points), sometimes (2 points), and yes (4 points). A higher score of THI indicateed more severe tinnitus. |
| tinnitus functional index (TFI) | the exact day of the first visit and review visit, within 3 - 4.5 months | The TFI scale assessed tinnitus-related distress and severity. It contained 8 subscales. They were denoted as TFI-I (Intrusiveness) and TFI-SC (Sense of) control), TFI-C (Cognition), TFI-S (Sleep), TFI-A (Auditory), TFI-R (Relaxation), TFI-Q (Quality of life), TFI-E (Emotional) distress); A total of 25 items are included. Each item worthes 100 points. The average score of all items was recorded as the total TFI score (0-100). A higher score of TFI indicateed more severe tinnitus. |
| pure tone audiometry | the exact 1 day of the first visit | The air conductivity threshold of pure tone audiometry across the frequency range of 500-4000Hz is referred to as the pure tone average (PTA) for the tested ear |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pittsburgh sleep quality index (PSQI) | the exact 1 day of the first visit and review visit, within 3 - 4.5 months | PSQI scale was compiled by Buysse et al in 1989 to assess the sleep quality of individuals in the last 1 month. The total score ranges from 0 to 21. A higher score indicates worse sleep quality in the past month. |
| Hamilton Depression Scale -24 items (HAMD-24) | the exact 1 day of the first visit and review visit, within 3 - 4.5 months | The HAMD-24 was used to assess the degree of depression and emotional state in patients with chronic subjective tinnitus. The assessment included the emotional state and symptoms of autonomic nervous system disorders in the past week, and each question was scored according to the presence and severity of symptoms. |
| visual analogue scale (VAS) | the exact 1 day of the first visit and review visit, within 3 - 4.5 months | VAS scaled from 0 to 10. A score of 0 means that tinnitus has no impact on daily life, and a score of 10 means that tinnitus has an intolerable, fatal level of impact on daily life. |
Outcome results
None listed