The Effects of Programmed Death-ligand 1 on Postoperative Pain for Lung Cancer Patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06503432

Enrollment

100

Registered

2024-07-16

Start date

2024-07-20

Completion date

2025-03-31

Last updated

2024-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer, Postoperative Pain

Brief summary

The concentration of plasma programmed death-ligand 1(PD-L1) for lung cancer patients before video-assisted thoracoscopic surgery is detected. According to the distribution of plasma concentration, patients are divided into high or low expression of PD-L1. Differences in acute and chronic postoperative pain are compared between two groups of patients. And effects of PD-L1 expresion on postoperative pain in lung cancer patients are explained.

Detailed description

Chronic pain after video-assisted thoracoscopic surgery (VATS) has been a major concern for lung cancer patients. The relationship between plasma programmed cell death ligand-1 (PD-L1) concentration and chronic pain in post-VATS is uncertain. This study aims to explore the effects of PD-L1 levels on chronic pain and provide proactive pain management regimen according to individual genetic differences. The concentration of plasma PD-L1 for lung cancer patients before video-assisted thoracoscopic surgery is detected. According to the distribution of plasma concentration, patients are divided into high or low expression of PD-L1. Differences in acute and chronic postoperative pain are compared between two groups of patients. And effects of PD-L1 expresion on postoperative pain in lung cancer patients are explained.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. American Society of Anesthesiologists physical status I-IV (males and females). 2. 18-80 years of age. 3. Patients undergoing video-assisted thoracoscopic surgery for malignant lung disease.

Exclusion criteria

1. History of opioid abuse. 2. Known psychiatric disorders. 3. Unexpected conversion to thoracotomy or transferred to intensive care unit for further treatment. 4. Combined with other surgeries or sites.

Design outcomes

Primary

Measure	Time frame	Description
the incidence of chronic pain after surgery	3 months after surgery	Patients were followed up by the Brief Pain Inventory questionnaire about the details of chronic pain.

Countries

China

Contacts

Primary ContactXue Tian, MD

justine_troy@163.com88325581

Outcome results