Frailty, Hyperglycemia, Hyperlipidemia, Sarcopenia
Conditions
Brief summary
Background: This investigation aims to explore efficacy of Taiwanese whole grain job's tear on muscle health and blood glucose and lipid levels in community-dwelling older adults. Methods: An open-label, 16-week, randomized controlled, cross-over trial involving participants with subject complaint of slower gait or weakness or fall in last year were recruited. The intervention group consumed Taiwanese whole grain job's tear (red job's tear) or white job's tear. Assessments included laboratory tests, functional assessments, and body composition.
Interventions
BIOLOGICALTaiwanese whole grain job's tear (red job's tear)
300cc drink made from red job's tear, 2 bottle/day from week 0 to week 8
BIOLOGICALWhite job's tear
300cc drink made from white job's tear, 2 bottle/day from week 0 to week 8
Sponsors
Taichung District Agricultural Research and Extension Station, Ministry of Agriculture, Taiwan
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
People who aged 60-95 years Patients with following characteristics: feeling loss in activity detecting decline in self's walking speed. feeling tired of doing everything. having fall event in last year. People willing to follow the program and cooperate with us for following tracking. People who are neither vegan nor vegetarian People agree and be able to sign the informed consent.
Exclusion criteria
People with any disease affecting their limbs, including: having fracture on limbs in the past 6 months having severe arthritis in the past 6 months any other whom PI recognized as weak control of their nervous system( e.g.: Parkinson's disease and stroke). People with intermittent limp caused by peripheral artery diseases People with weak control of mental disorder People with weak control of Cardiopulmonary disease People with weak control of Malignant tumor People with weak control of kidney diseases (eGFR \<60ml/min/1.73) People with Visual impairment and Hearing disorder which cannot help to complete the program. People who have underwent hormone treatment and planned to undergo hormone treatment during program session. Any other condition that PI recognized as not suitable
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of appendicular skeletal muscle index(ASMI) | 0, 8, 16 week | ASMI=appendicular skeletal muscle mass(kg)/(height(m)2) |
| Changes of handgrip strength | 0, 8, 16 week | Maximal handgrip strength of dominant hand (kg) |
| Changes of gait speed | 0, 8, 16 week | Usual gait speed measured by 6-meter walking (m/s) |
| Changes of time required to finish timed up and go(TUG) test | 0, 8, 16 week | Changes of time required to finish timed up and go(TUG) test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of muscle biomarker 2 | 0, 8 week | Measured by serum follistatin |
| Changes of inflammation marker | 0, 8, 16 week | defined by hsCRP |
| Changes of muscle biomarker 3 | 0, 8 week | Measured by serum activin A |
| Changes of insulin resistance | 0, 8, 16 week | Measured by HOMA-IR |
| Changes of LDL | 0, 8, 16 week | Changes of LDL |
| Changes of muscle biomarker 1 | 0, 8 week | Measured by serum myostatin |
Countries
Taiwan
Contacts
Primary ContactAnchun Hwang, Doctor
Outcome results
None listed