Association Between Iron Reserves and Perioperative Neurocognitive Disorders

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06502912

Enrollment

12984

Registered

2024-07-16

Start date

2014-01-01

Completion date

2021-12-31

Last updated

2024-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Neurocognitive Disorders

Keywords

iron reserves, Perioperative neurocognitive disorders, elderly, iron overload

Brief summary

Iron metabolism disorder have been identified as the pivotal contributor in the pathogenesis and progression of perioperative neurocognitive disorders. However, the association between iron reserves and perioperative neurocognitive disorders risk remains elusive. This retrospective cohort study aimed to explore the impact of preoperative serum ferritin levels on the risk of postoperative delirium in elderly patients undergoing non-neurosurgical and non-cardiac procedures.

Interventions

OTHERno intervention

no intervention

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Geriatric surgical patients ≥65 years old

Exclusion criteria

* preoperative use of antipsychotics * diagnosis or history description of preoperative cognitive disorders including dementia and Parkinson's

Design outcomes

Primary

Measure	Time frame	Description
Number of participants with postoperative delirium	Within the first seven days following surgery	Medical chart review was used for postoperative delirium determination in this study. The defining criteria were as follows: 1) delirium-related terms included in postoperative medical records or 2) postoperative record of delirium or psychotropic drugs treatment.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026