ABO Hemolytic Disease, ABO Incompatibility, Neonatal Jaundice From Other Specified Causes
Conditions
Brief summary
Neonatal jaundice is a major global health issue that can lead to serious complications and even death if not promptly treated. ABO incompatibility is a common cause of pathological neonatal jaundice, but there are currently no specific tests to predict its severity or progression. This project aims to study the role of exosomes in the diagnosis and treatment of newborn jaundice, focusing on their impact on infants with ABO incompatibility. The study will take place at a reference neonatal intensive care unit, involving 45 infants. Serum and breast milk samples will be collected and analyzed to determine any relationships and possible correlations.
Interventions
OTHERExosome profile study
Neonatal serum and maternal exosome profiles will be studied in all groups.
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 28 Days
Inclusion criteria
* Newborns who are needed treatment for neonatal jaundice due to ABO incompatibility * Newborns who are admitted to the study center due to ABO hemolytic disease * Newborns with ABO incompatibility * Healthy newborns * Healthy mothers
Exclusion criteria
* Lack of informed consent * Congenital abnormalities * Maternal Liver diseases * Neonatal liver diseases * Sepsis * Neonatal jaundice due to the causes other than ABO incompatibility * Acute or chronic disease state in newborn * Maternal acute or chronic disease * Medication or substance use effecting liver functions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of the participant who Need for Treatment | 12 months | Association between the serum and breastmilk exosome and need for treatment due to ABO incompability |
Countries
Turkey (Türkiye)
Outcome results
None listed