Asthma
Conditions
Brief summary
The purpose of this study was to examine whether electrical impedance tomography (EIT) was capable of identifying the deteriorated lung function on a regional level during bronchial challenge testing and whether EIT may provide additional information during bronchial challenge testing and identify spatial and temporal heterogeneity of regional lung function.
Detailed description
The content of this study includes: 1. Can EIT identify the uneven ventilation caused by airway contraction in patients during bronchial provocation tests. 2. Can EIT monitor airway contraction in patients before Spirometer examination after inhaling activators. 3. Can EIT observe uneven ventilation caused by airway contraction through tidal breathing after the patient inhales activator.
Interventions
None listed
Sponsors
wang kaifei
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
： 1. Patients suspected of asthma who require bronchial challenge testing. 2. The Bronchodilator responsiveness testing is negative. 3. patients with a pre-bronchodilator FEV1 \>60% predicted. 4. No contraindications for bronchial provocation test examination. 5. Fully understand the purpose and significance of this study, and voluntarily participate in the research.
Exclusion criteria
1\. patients with a pre-bronchodilator FEV1≤60% predicted. 1. Contraindications for bronchial challenge testing. 2. Pregnant or lactating women. 3. After pacemaker surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| global inhomogeneity index （GI） | 1day | Measured by EIT, used to describe the overall degree of spatial heterogeneity of ventilation. |
| forced expiratory volume in 1s (FEV1) | 1day | The forced expiratory volume in 1s measured during pulmonary function tests. |
Contacts
Primary ContactLu Cao, Master
Outcome results
None listed