Full Spectrum
Conditions
Keywords
myopia,spectrum,vegetative nerve,pupil
Brief summary
Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by the excitability of the parasympathetic nervous system. This study intends to compare pupil size and area, as well as parameters regulated by the autonomic nervous system (such as skin bioelectrical activity and heart rate), between LEDs with a full visible spectrum and LEDs with a partially absent spectrum around 470nm and 730nm. We aim to elucidate the physiological mechanism underlying the effect of light spectrum on pupil changes and myopia.
Interventions
Subjects will stay in a room with full spectrum light for 5 minutes. After 5 minutes wash-out period, altenate to the other arm.
OTHERspecific spectrum absence light exposure
Subjects will stay in a room with ordinary LED light for 5 minutes. After 5 minutes wash-out period, altenate to the other arm.
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
7 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 1\. Age 7-45 years 2. Able to wear multi-channel physiological measurement devices and cooperate with experimental procedures. 3\. Binocular? spherical power between -0.50 to -5.00 diopters, and cylinder power no more than -1.50 diopters. 4\. Voluntarily participate in this study with informed consent form signed.
Exclusion criteria
* 1\. History of diseases affecting autonomic nervous system function, such as depression and anxiety. 2\. History of eye diseases such as strabismus, amblyopia, keratitis, and glaucoma, which are unsuitable for eye movement test. 3\. History of major systemic diseases or surgeries such as cranial surgery, myocardial infarction, or stroke. 4\. Systemic medication history that may affect autonomic nervous system function, including but not limited to antidepressants, antihistamines, anticholinergics, antipsychotics, and sedative-hypnotic drugs like diazepam or lorazepam. 5\. Use of eyedrops such as mydriatics or miotics that will affect pupil size. 6. Having difficulty in understanding and cooperating with the trial, such as those with disabilities, communication barriers, or those unable to undertake examinations. 7\. Other contradictions that the physician may consider inappropriate for enrolment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pupil size | 5 minutes | The pupil diameter is measured in real-time using the Eyelink Portable Duo eye tracker. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory movement | 5 minutes | The amplitude of respiratory movements measured in real-time using the Biopac MP160 multi-channel physiological recorder. |
| Pulse pressure waveform | 5 minutes | The amplitude of respiratory movements measured in real-time using the Biopac MP160 multi-channel physiological recorder. |
| Spherical equivalent refraction | 5 minutes | Measured with autorefractor and defined as the sum of spherical power and half of the cylinder power. |
| Skin conductance response | 5 minutes | Rapidly changing and short-duration skin surface potentials measured in real-time using the Biopac MP160 multi-channel physiological recorder. |
| Axial length | 5 minutes | Uncorrected visual acuity: Visual acuity without refractive correction. |
| Corneal curvature | 5 minutes | Anterior corneal curvature measured by the Pentacam corneal topographer |
| Uncorrected visual acuity | 5 minutes | Visual acuity without refractive correction. |
Contacts
Primary ContactZeng Yangfa, Master's
Outcome results
None listed