Septic Shock
Conditions
Keywords
septic shock, hemodynamic resuscitation, cardiovascular monitoring
Brief summary
Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation. Hemodynamic and metabolic parameters before and after a fluid challenge (FC) will be measured.
Interventions
OTHERFluid challenge
Rapid infusion (\< 15 minutes) of a fluid bolus of crystalloids (200 to 500cc)
Sponsors
Corporacion Parc Tauli
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion (elevated lactate and/or ScvO2 \< 70%).
Exclusion criteria
* Age under 18 years old * Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (\> 10% from baseline dose) within the 15-minute period prior to, and/or during the administration of fluids. * Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VO2-response | 30 minutes | Percentage increase in VO2 as results of the fluid challenge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Organ failure | 4 days | Assessment of the SOFA score at day 1, 2 and 4 |
| Mortality | 28 days | Mortality within the first 28 days |
Countries
Spain
Contacts
Primary ContactJaume Mesquida, MD
Backup ContactFerran Oller, MD
Outcome results
None listed