Etiology and Prognosis of sICH Based on Hemorrhage Location

Prediction of Etiology and Prognosis Based on Hematoma Location of Spontaneous Intracerebral Hemorrhage

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06498778

Enrollment

698

Registered

2024-07-12

Start date

2021-07-01

Completion date

2023-05-31

Last updated

2024-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spontaneous Intracerebral Hemorrhage

Keywords

Normative analysis; Lesion-symptom mapping; Radiomics; Etiological classification; Machine learning

Brief summary

The investigators retrospectively collected participants with spontaneous cerebral hemorrhage(sICH) from January 2015 to December 2019 for training and internal validation. Clinical and imaging data were collected. Modified Rankin Scale (mRS) scores were determined good outcome as mRS = 0-2, poor outcome as mRS = 3-6. The location features of sICH were extracted by symptom mapping. Noncontrast computed tomography images of patients and hematoma masks were registered with standard human brain templates to identify specific affected brain regions. Then a probability map of hemorrhage for different causes and prognosis is generated. PyRadiomics was used to extract the radiomic features, integrate radiomic and clinical features into multiple logistic regression models, and develop and validate optimal etiological and prognostic models. Further tests were performed in an independent cohort. The area under the working characteristic curve (AUC), sensibility, specificity were used to evaluate the reliability of the model.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* The confirmation of intracranial hemorrhage was achieved through NCCT.

Exclusion criteria

* They presented with secondary hemorrhage resulting from head trauma, hemorrhagic transformation of ischemic infarction, brain tumors, or exhibited abnormalities in blood coagulation, liver, kidney function, or were subject to drug-induced cerebral hemorrhage * Only postoperative CT images were available * Lost follow-up records * CT image artifacts

Design outcomes

Primary

Measure	Time frame	Description
Modified Rankin Scale (mRS) scores	follow-ups at twelve months post sICH event	Good outcome as mRS = 0-2, poor outcome as mRS = 3-6

Countries

China

Outcome results