Subanesthetic Ketamine Dexmedetomidin
Conditions
Keywords
Ketamine, Dexmedetomidine ,Post-traumatic Stress Disorder , traumatic Brain surgeries
Brief summary
Prevention of Post-traumatic Stress Disorder after traumatic Brain surgeries by using either subanesthetic ketamine or dexmedetomidine infusion.
Detailed description
after being informed about the study and potential risks. All patients giving written consent will be randomized by double blind manner into two equal groups (K group and D group). Using computer generated randomization table; each group consists of 26 patients: K group (n=26): Patient will receive with 0.5 mg/kg/h ketamine infusion. D group (n=26): Patient will receive 0.1 ug/kg/h dexmedetomidine infusion.
Interventions
DRUGketamine
0.5 mg/kg/h ketamine infusion
DRUGdexmedetomidine
0.1 ug/kg/h dexmedetomidine infusion
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Aged 18-60 years old.Body mass index of less than or equal 35.American Society of I and II.Duration of surgery not more than 3 hours.
Exclusion criteria
Known hypersensitivity to dexmedetomidine or ketamine. Hemorrhagic shock decompensation.History of alcohol or drug abuse.History of neurologic or psychiatric diseases Advanced renal ,liver or cardiovascular disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| (PTSD) | 6 months | To measure the change in PTSD symptom severity using the PTSD Checklist |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| VAS | (24 hours, 48 hours, and 1 month) | postoperative pain |
| postoperative delirium | twice daily for 3 days | using the confusion assessment method criteria |
Countries
Egypt
Outcome results
None listed