Assessment of the Efficacy of Microosteoperforations Versus Injectable Platelet-rich Fibrin During Orthodontic Leveling and Alignment of Mandibular Incisors

Assessment of the Efficacy of Microosteoperforations Versus Injectable Platelet-rich Fibrin During Orthodontic Leveling and Alignment of Mandibular Incisors: A Comparative Clinical Trial

Status

Enrolling by invitation

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06498609

Enrollment

Registered

2024-07-12

Start date

2024-08-01

Completion date

2024-12-01

Last updated

2024-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of Platelet Rich Fibrin Versus Microosteoperforation Compaed to Control Group Toothmovement

Brief summary

The aim of this prospective clinical study will be to compare the efficacy of micro osteoperforations versus injectable platelet-rich fibrin during orthodontic leveling and alignment of mandibular incisors.

Interventions

BIOLOGICALiprf

i-PRF with leveling and alignment

PROCEDUREMOPs with leveling and alignment

mop

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

15 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

1. An age range from 15 to 25 years. 2. Participants who had a full set of permanent dentitions excluding the third molar. 3. Participants who had moderate crowding in the mandibular arch according to Little's irregularity index that necessitates non-extraction treatment in the mandibular arch. 4. Normal vertical facial proportions. 5. Participants who had good oral hygiene and no periodontal disease. 6. No systemic diseases or regular medication that could interfere and/or affect orthodontic teeth movement. 7. No evidence of craniofacial anomalies, such as clef lip and palate or previous history of trauma, bruxism, or parafunction. 8. No tooth size, shape, or root abnormalities visible on patient's radiographic records.

Exclusion criteria

1. Previous orthodontic treatment. 2. Any skeletal dysplasia or craniofacial malformation. 3. Retained primary or missing permanent teeth in the anterior area, and any kind of tooth/root shape anomaly or history of trauma affecting the incisors. 4. Systemic diseases or regular use of medications that could interfere with OTM. 5. Patients with root resorption, impacted canines, or dental anomalies. 6. Poor oral hygiene and uncontrolled periodontal diseases.

Design outcomes

Primary

Measure	Time frame	Description
assessment of acceleration of leveling and alignment of mandibular incisors	post interventional at 4months	rate of leveling and alignment

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026