Sleep-Disordered Breathing
Conditions
Keywords
Periodic breathing, Hypoxia, Prevention, Acetazolamide, Women, Altitude
Brief summary
Prospective cohort study investigating the menstrual cycle phase (MCP) dependent sleep disordered breathing (SDB) in women travelling to 3600 m.
Interventions
OTHERExposure to 3600 m
Participants will travel to and stay for 2 nights at an altitude of 3600 m.
Sponsors
University of Zurich
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
University Hospital Heidelberg
Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
Criteria: Inclusion Criteria: * Healthy, non-smoking women, age 18-44 years, without any diseases and need of regular medication (including oral contraceptives). * BMI \>18 kg/m2 and \<30 kg/m2 * Born, raised and currently living at altitudes \<1000 m * Written informed consent * Premenopausal, eumenorrheic cycle
Exclusion criteria
* Other types of contraceptives (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others) * Pregnancy or nursing * Anaemic (haemoglobin concentration \<10g/dl) * Any altitude trip \<4 weks before the study * Allergy to acetazolamide and other sulfonamides
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nocturnal oxygen saturation (SpO2) | Night 1 at 760 m and Night 1 at 3600 m | MCP-related difference in altitude-induced change in the mean nocturnal oxygen saturation measured by pulse oximetry. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nocturnal oxygen desaturation index (ODI) | Night 1 at 760 m and Night 1 at 3600 m | MCP-related difference in altitude-induced change in the ODI (number of ∆SpO2 \>3% per hour time in bed measured by pulse oximetry). |
| Apnea/hypopnea index (AHI) | Night 1 at 760 m and Night 1 at 3600 m | MCP-related difference in altitude-induced change in the mean number of apneas/hypopneas per hour. |
| Subjective sleep quality | Night 1 at 760 m and Night 1 at 3600 m | MCP-related difference in altitude-induced change in subjective sleep quality assessed by a 100-mm visual analog scale. |
| Nocturnal oxygen saturation (SpO2) | Night 1 at 760 m and Night 2 at 3600 m | MCP-related difference in altitude-induced change in the mean nocturnal oxygen saturation measured by pulse oximetry. |
Countries
Kyrgyzstan
Contacts
STUDY_CHAIRMichael Furian, Prof. Dr.
University of Zurich
STUDY_DIRECTORTalant Sooronbaev, Prof. Dr.
National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
Outcome results
None listed